NOTCH1/activated Notch1 Antibody

• Catalog number
  bs-11976R
• Price
  Please ask
• Size
  0.1ml

• Long name
  NOTCH1/activated Notch1 Antibody
• Also known as
  NOTCH1/activated Notch1 Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  NOTCH1/activated Notch1
• Specificity
  This is a highly specific antibody against NOTCH1/activated Notch1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NOTCH1/activated Notch1
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The LIN-12/notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for notch include Jagged1, Jagged2 and Delta. Jagged can activate notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions. Normal Delta expression is restricted to the adrenal gland and placenta. Delta expression has also been found in neuroendocrine tumors such as neuroblastomas and pheochromocytomas.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  hN1; Neurogenic locus Notch homolog protein 1; activated Notch 1; activated Notch-1;Notch homolog 1 translocation associated Drosophila; NOTCH1; TAN1; Translocation-associated Notch protein TAN-1;
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NOTCH1/activated   Notch1  
• Gene symbol
  NOTCH1
• Short name
  Anti-NOTCH1/activated Notch1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  NOTCH1/activated Notch1 Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  notch 1, AOS5 and AOVD1 and hN1 and TAN1, NOTCH1 and IDBG-92445 and ENSG00000148400 and 4851, sequence-specific DNA binding, nuclei, Notch1 and IDBG-149571 and ENSMUSG00000026923 and 18128, NOTCH1 and IDBG-640538 and ENSBTAG00000022799 and 767866

Gene info

• Identity
  HGNC:7881
• Gene
  NOTCH1
• Long gene name
  notch receptor 1
• Synonyms gene
  • TAN1
• Synonyms gene name
  • Notch (Drosophila) homolog 1 (translocation-associated)
  • Notch homolog 1, translocation-associated (Drosophila)
  • notch 1
• GenBank acession
  • AF308602
• Locus
  9q34.3
• Discovery year
  1992-02-13
• Entrez gene record
  4851
• Pubmed identfication
  • 1831692
• RefSeq identity
  • NM_017617
• Classification
  • Notch receptors
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000020935
• Locus Specific Databases
  • LRG_1122

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products