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Long name
NMDAR3A + 3B Primary Polyclonal Antibody
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Also known as
NMDAR3A + 3B PAb
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Category
Primary Antibodies
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Conjugation
Unconjugated
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Target Antigen
NMDAR3A + 3B
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Specificity
This is a highly specific antibody against NMDAR3A + 3B.
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Modification s
None
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Modification site s
Unmodified antibody
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Clonality
Polyclonal antibody
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Clone number
Polyclonal antibody
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Concentration
1ug per 1ul
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NMDAR3A + 3B
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Tested Applications
WB, IHC-P, IF(IHC-P)
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Recommended dilutions
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigen
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neuro-degeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to 7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions. One such NMDA receptor, NR3B, is expressed in motor neurons and forms cation channels impermeable to calcium, which can resist many open-channel blockers. NR3B functions in the brain as an excitatory glycine receptor, modifying the normal role of glycine as an inhibitory neurotransmitter.
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Purification method
This antibody was purified via Protein A.
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Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym names
Glutamate Receptor Ionotropic N methyl D aspartate 3A; Glutamate Receptor Ionotropic N methyl D aspartate 3B; Glutamate Receptor Ionotropic N-methyl-D-aspartate 3A; Glutamate Receptor Ionotropic N-methyl-D-aspartate 3B; GRIN3A; GRIN3B; NMDA receptor subunit 3A; NMDA receptor subunit 3B; NMDA Type Glutamate Receptor Subunit NR3B Precursor; NMDAR-L; NR3A; NR3B; NMD3B_HUMAN; NMD3A_HUMAN。
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Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps