NEDD4 Antibody
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Catalog numberbs-7877R
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PricePlease ask
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Size0.1ml
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Long nameNEDD4 Primary Polyclonal Antibody
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Also known asNEDD4 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenNEDD4
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SpecificityThis is a highly specific antibody against NEDD4.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range861-890/1319
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NEDD4
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Gene ID number4734
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Swiss ProtP46934
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenE3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesRPF1; NEDD4-1; E3 ubiquitin-protein ligase NEDD4; Cell proliferation-inducing gene 53 protein; Neural precursor cell expressed developmentally down-regulated protein 4; NEDD-4; NEDD4; KIAA0093; PIG53
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolNEDD4, NEDD4L
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Short nameAnti-NEDD4
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameNEDD4 Polyclonal Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameNEDD4 E3 ubiquitin protein ligase
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Synonyms gene name
- neural precursor cell expressed, developmentally down-regulated 4
- neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1994-01-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- HECT domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNEDD4 like E3 ubiquitin protein ligase
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Synonyms gene name
- neural precursor cell expressed, developmentally down-regulated 4-like
- neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-03-14
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Entrez gene record
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Pubmed identfication
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Classification
- HECT domain containing
- C2 domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data