MYPT1 (Ser507) Antibody

• Catalog number
  bs-3285R
• Price
  Please ask
• Size
  0.1ml

• Long name
  MYPT1 (Ser507) Primary Polyclonal Antibody
• Also known as
  MYPT1 (Ser507) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  MYPT1 Ser507
• Specificity
  This is a highly specific antibody against MYPT1 Ser507.
• Modification s
  Phosphorylation
• Modification site s
  Ser507
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human MYPT1 around the phosphorylation site of Ser507
• Gene ID number
  4659
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate(GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Myosin Phosphatase phospho Ser507; p-MBSSer507; Myosin Phosphatase phospho S507; p-MYPT1Ser507; Myosin Phosphatase; M130; MBS; MGC133042; Myosin phosphatase target subunit 1; Myosin phosphatase targeting subunit 1; MYPT 1; MYPT1; PPP1R12A; Protein phosphatase 1 regulatory inhibitor subunit 12A; Protein phosphatase 1 regulatory subunit 12A; Protein phosphatase myosin binding subunit; MYPT1_HUMAN; Myosin phosphatase-targeting subunit 1; Protein phosphatase myosin-binding subunit.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MYPT1   Ser507  
• Gene symbol
  PPP1R12A
• Short name
  Anti-MYPT1 Ser507
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  MYPT1 (Ser507) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7618
• Gene
  PPP1R12A
• Long gene name
  protein phosphatase 1 regulatory subunit 12A
• Synonyms gene
  • MYPT1
• Synonyms gene name
  • protein phosphatase 1, regulatory (inhibitor) subunit 12A
  • protein phosphatase 1, regulatory subunit 12A
• Synonyms
  • MBS
  • M130
• Synonyms name
  • myosin phosphatase-targeting subunit 1
  • myosin binding subunit
• GenBank acession
  • D87930
• Locus
  12q21.2-q21.31
• Discovery year
  1997-12-23
• Entrez gene record
  4659
• Pubmed identfication
  • 9286714
• RefSeq identity
  • NM_002480
• Classification
  • Ankyrin repeat domain containing
  • Myosin phosphatase targeting family
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000170100

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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