MTMR2 Antibody

• Catalog number
  bs-11733R
• Price
  Please ask
• Size
  0.1ml

• Long name
  MTMR2 Primary Polyclonal Antibody
• Also known as
  MTMR2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  MTMR2
• Specificity
  This is a highly specific antibody against MTMR2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MTMR2
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CMT4B; CMT4B1; KIAA1073; MTMR2; MTMR2_HUMAN; Myotubularin related protein 2; Myotubularin-related protein 2.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MTMR2  
• Gene symbol
  MTMR2
• Short name
  Anti-MTMR2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  MTMR2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7450
• Gene
  MTMR2
• Long gene name
  myotubularin related protein 2
• Synonyms gene
  • CMT4B
• Synonyms
  • KIAA1073
• Synonyms name
  • phosphatidylinositol-3-phosphatase
  • phosphoinositide-3-phosphatase
• GenBank acession
  • U58033
• Locus
  11q21
• Discovery year
  1999-02-05
• Entrez gene record
  8898
• Pubmed identfication
  • 8640223
  • 9736772
• RefSeq identity
  • NM_016156
• Classification
  • Phosphoinositide phosphatases
  • Myotubularins
• VEGA ID
  OTTHUMG00000153837
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LRG_257

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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