MLLT11 Antibody
-
Catalog numberbs-8562R
-
PricePlease ask
-
Size0.1ml
-
-
Long nameMLLT11 Primary Polyclonal Antibody
-
Also known asMLLT11 PAb
-
CategoryPrimary Antibodies
-
ConjugationUnconjugated
-
Target AntigenMLLT11
-
SpecificityThis is a highly specific antibody against MLLT11.
-
Modification sNone
-
Modification site sUnmodified antibody
-
ClonalityPolyclonal antibody
-
Clone numberPolyclonal antibody
-
Concentration1ug per 1ul
-
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MLLT11
-
Gene ID number10962
-
Tested ApplicationsIHC-P, IF(IHC-P)
-
Recommended dilutionsIHC-P(1:100-500), IF(IHC-P)(1:50-200)
-
Cross reactivityHuman, Mouse, Rat
-
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigenThe gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. MLLT11, also known as mixed-lineage leukemia translocated to 11 or AF1q, is a 90 amino acid MLL fusion partner. Based on the expression patterns of MLLT11, it is thought that MLLT11 plays a role in leukemogenesis and, specifically, the progression of acute monocytic leukemia (AML). Also, expressed in embryonic brain cortex, MLLT11 is upregulated during neuronal differentiation and is thought to play a role in the development of the central nervous system. Finally, MLLT11 has been shown to be differentially expressed in highly metastatic cells, in comparison with non-metastatic parent cells. Such findings suggest a role of MLLT11 in tumorigenesis.
-
Purification methodThis antibody was purified via Protein A.
-
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym namesAF1Q; ALL1 fused gene from chromosome 1q; MLLT 11; MLLT-11; Myeloid/lymphoid or mixed lineage leukemia trithorax homolog, Drosophila translocated to 11; Protein AF1q; RP11 316M1.10.
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolMLLT11
-
Short nameAnti-MLLT11
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
HostRabbit (Oryctolagus cuniculus)
-
IsotypeImmunoglobulin G (IgG)
-
Alternative nameMLLT11 Polyclonal Antibody
-
Alternative techniqueantibodies
-
Alternative to gene targetmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, AF1Q, MLLT11 and IDBG-244926 and ENSG00000213190 and 10962, molecular_function, multiple, Mllt11 and IDBG-171976 and ENSMUSG00000053192 and 56772, MLLT11 and IDBG-633245 and ENSBTAG00000015369 and 539519
-
Gene info
-
Identity
-
Gene
-
Long gene nameMLLT11 transcription factor 7 cofactor
-
Synonyms gene name
- myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
- myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2005-05-23
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data