MDM2 Antibody

• Catalog number
  bs-1043R
• Price
  Please ask
• Size
  0.1ml

• Long name
  MDM2 Primary Polyclonal Antibody
• Also known as
  MDM2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  MDM2
• Specificity
  This is a highly specific antibody against MDM2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  440-491/491
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MDM2
• Gene ID number
  4193
• Swiss Prot
  Q00987
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  HDMX; hdm2; ACTFS; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Oncoprotein Mdm2; p53-binding protein Mdm2; MDM2
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MDM2  
• Gene symbol
  MDM2
• Short name
  Anti-MDM2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  MDM2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6973
• Gene
  MDM2
• Long gene name
  MDM2 proto-oncogene
• Synonyms gene name
  • mouse double minute 2, human homolog of; p53-binding protein
  • Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)
  • Mdm2 p53 binding protein homolog (mouse)
  • MDM2 proto-oncogene, E3 ubiquitin protein ligase
• Synonyms
  • HDM2
  • MGC5370
• Locus
  12q15
• Discovery year
  1993-12-10
• Entrez gene record
  4193
• Pubmed identfication
  • 1614537
  • 16905769
  • 29123033
• RefSeq identity
  • NM_002392
• Classification
  • Zinc fingers RANBP2-type
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000142827

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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