MDC1 Antibody

• Catalog number
  bs-2400R
• Price
  Please ask
• Size
  0.1ml

• Long name
  MDC1 Primary Polyclonal Antibody
• Also known as
  MDC1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  MDC1
• Specificity
  This is a highly specific antibody against MDC1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  45-90/2089
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MDC1
• Gene ID number
  9656
• Swiss Prot
  Q14676
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  NFBD1; Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1; MDC1; KIAA0170
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MDC1  
• Gene symbol
  MDC1-AS1, MDC1
• Short name
  Anti-MDC1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  MDC1 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  mediator of DNA-damage checkpoint 1, NFBD1, MDC1 and IDBG-76700 and ENSG00000137337 and 9656, FHA domain binding, nuclei, Mdc1 and IDBG-179187 and ENSMUSG00000061607 and 240087, MDC1 and IDBG-634528 and ENSBTAG00000025526 and 511168

Gene info

• Identity
  HGNC:39764
• Gene
  MDC1-AS1
• Long gene name
  MDC1 antisense RNA 1
• Synonyms gene name
  • MDC1 antisense RNA 1 (non-protein coding)
• Synonyms
  • MDC1-AS
• Locus
  6p21.33
• Discovery year
  2011-04-21
• Entrez gene record
  106478956
• Pubmed identfication
  • 25514464
  • 27261595
• RefSeq identity
  • NR_133647
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000133551

Gene info

• Identity
  HGNC:21163
• Gene
  MDC1
• Long gene name
  mediator of DNA damage checkpoint 1
• Synonyms gene name
  • mediator of DNA-damage checkpoint 1
• Synonyms
  • NFBD1
  • KIAA0170
  • Em:AB023051.5
• GenBank acession
  • D79992
• Locus
  6p21.33
• Discovery year
  2003-05-21
• Entrez gene record
  9656
• Pubmed identfication
  • 10975465
  • 12607005
• RefSeq identity
  • NM_014641
• VEGA ID
  OTTHUMG00000031075

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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