KIRREL1 Antibody

• Catalog number
  bs-6435R
• Price
  Please ask
• Size
  0.1ml

• Long name
  KIRREL1 Primary Polyclonal Antibody
• Also known as
  KIRREL1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  KIRREL1
• Specificity
  This is a highly specific antibody against KIRREL1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KIRREL1/NEPH1
• Gene ID number
  55243
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Neph1(Kirrel) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain and a cytoplasmic tail. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice results in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death..Tissue specificity:Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Kin of IRRE like Drosophila; Kin of IRRE like; Kin of IRRE like protein 1; Kin of IRRE-like protein 1; Kin of irregular chiasm like protein 1; Kin of irregular chiasm-like protein 1; KIRR1_HUMAN; Kirrel; MGC129542; MGC129543; NEPH 1; NEPH1; Nephrin like protein 1; Nephrin related; Nephrin-like protein 1; KIRR1_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  KIRREL1  
• Gene symbol
  KIRREL1, KIRREL1-IT1
• Short name
  Anti-KIRREL1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  KIRREL1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:15734
• Gene
  KIRREL1
• Long gene name
  kirre like nephrin family adhesion molecule 1
• Synonyms gene
  • KIRREL
• Synonyms gene name
  • kin of IRRE like (Drosophila)
• Synonyms
  • NEPH1
• Synonyms name
  • nephrin-like protein 1
• GenBank acession
  • AK001707
• Locus
  1q23.1
• Discovery year
  2002-01-22
• Entrez gene record
  55243
• Pubmed identfication
  • 12424224
• RefSeq identity
  • NM_018240
• Classification
  • C2-set domain containing
  • I-set domain containing
• VEGA ID
  OTTHUMG00000022438

Gene info

• Identity
  HGNC:41412
• Gene
  KIRREL1-IT1
• Long gene name
  KIRREL1 intronic transcript 1
• Synonyms gene
  • KIRREL-IT1
• Synonyms gene name
  • KIRREL intronic transcript 1 (non-protein coding)
  • KIRREL intronic transcript 1
• Locus
  1q23.1
• Discovery year
  2011-05-23
• Entrez gene record
  100505785
• RefSeq identity
  • NR_145471
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000035615

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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