HIF1A (288CT11.7.1) Monoclonal Antibody

• Catalog number
  bsm-51085M
• Price
  Please ask
• Size
  0.1ml

• Long name
  HIF1A (288CT11.7.1) Monoclonal Antibody
• Also known as
  HIF1A (288CT11.7.1) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  HIF1A
• Specificity
  This is a highly specific antibody against HIF1A.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  288CT11.7.1
• Source
  This HIF1A monoclonal antibody is generated from mouse immunized with HIF1A recombinant protein.
• Gene ID number
  3091
• Swiss Prot
  Q16665
• Tested Applications
  WB
• Recommended dilutions
  WB(1:100~1000)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
• Purification method
  Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha; Hypoxia-inducible factor 1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; Member of PAS protein 1; PAS domain-containing protein 8; HIF1A
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  HIF1A   288CT11   Monoclonal  
• Gene symbol
  HIF1A-AS3, HIF1A-AS1, HIF1A-AS2, HIF1A
• Short name
  Anti-HIF1A
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgM κ
• Alternative name
  HIF1A (288CT11.7.1) Monoclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), bHLHe78 and HIF-1A and HIF-1alpha and HIF1 and HIF1-ALPHA and MOP1 and PASD8, HIF1A and IDBG-8510 and ENSG00000100644 and 3091, Hsp90 protein binding, nuclei, Hif1a and IDBG-148620 and ENSMUSG00000021109 and 15251, HIF1A and IDBG-646757 and ENSBTAG00000020935 and 281814

Gene info

• Identity
  HGNC:54284
• Gene
  HIF1A-AS3
• Long gene name
  HIF1A antisense RNA 3
• Locus
  14q23.2
• Discovery year
  2019-05-01
• Entrez gene record
  105370526
• RefSeq identity
  • NR_144368
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:43014
• Gene
  HIF1A-AS1
• Long gene name
  HIF1A antisense RNA 1
• Synonyms gene name
  • HIF1A antisense RNA 1 (non-protein coding)
• Synonyms
  • 5'aHIF-1A
• GenBank acession
  • CN270307
• Locus
  14q23.2
• Discovery year
  2011-09-16
• Entrez gene record
  100750246
• Pubmed identfication
  • 21897117
  • 24875884
• RefSeq identity
  • NR_047116
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000171134

Gene info

• Identity
  HGNC:43015
• Gene
  HIF1A-AS2
• Long gene name
  HIF1A antisense RNA 2
• Synonyms gene name
  • HIF1A antisense RNA 2 (non-protein coding)
• Synonyms
  • 3'aHIF-1A
  • aHIF
• Locus
  14q23.2
• Discovery year
  2011-09-16
• Entrez gene record
  100750247
• Pubmed identfication
  • 21897117
  • 27018306
• RefSeq identity
  • NR_045406
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000171135

Gene info

• Identity
  HGNC:4910
• Gene
  HIF1A
• Long gene name
  hypoxia inducible factor 1 subunit alpha
• Synonyms gene name
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
• Synonyms
  • MOP1
  • HIF-1alpha
  • PASD8
  • HIF1
  • bHLHe78
• Synonyms name
  • PAS domain-containing protein 8”, “Class E basic helix-loop-helix protein 78”, “Member of PAS protein 1
• GenBank acession
  • U22431
• Locus
  14q23.2
• Discovery year
  1995-03-27
• Entrez gene record
  3091
• Pubmed identfication
  • 8786149
  • 9079689
• RefSeq identity
  • NM_001530
• Classification
  • Basic helix-loop-helix proteins
• VEGA ID
  OTTHUMG00000140344

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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