HDAC6 Antibody

• Catalog number
  bs-2811R
• Price
  Please ask
• Size
  0.1ml

• Long name
  HDAC6 Primary Polyclonal Antibody
• Also known as
  HDAC6 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  HDAC6
• Specificity
  This is a highly specific antibody against HDAC6.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  330-380/1215
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HDAC6
• Gene ID number
  10013
• Swiss Prot
  Q9UBN7
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  HD6; JM21; CPBHM; PPP1R90; Histone deacetylase 6; HDAC6; KIAA0901
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HDAC6  
• Gene symbol
  HDAC6
• Short name
  Anti-HDAC6
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  HDAC6 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  histone deacetylase 6, CPBHM and HD6 and PPP1R90, HDAC6 and IDBG-63929 and ENSG00000094631 and 10013, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, Hdac6 and IDBG-129835 and ENSMUSG00000031161 and 15185, BT.76413 and IDBG-636881 and ENSBTAG00000013244 and 513602

Gene info

• Identity
  HGNC:14064
• Gene
  HDAC6
• Long gene name
  histone deacetylase 6
• Synonyms
  • KIAA0901
  • JM21
  • HD6
  • FLJ16239
  • PPP1R90
• Synonyms name
  • protein phosphatase 1, regulatory subunit 90
• GenBank acession
  • AF132609
• Locus
  Xp11.23
• Discovery year
  2000-11-28
• Entrez gene record
  10013
• Pubmed identfication
  • 10220385
  • 10048485
• RefSeq identity
  • NM_006044
• Classification
  • Histone deacetylases, class IIB
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000034496
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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