Granzyme A Antibody
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Catalog numberbs-2578R
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PricePlease ask
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Size0.1ml
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Long nameGranzyme A Primary Polyclonal Antibody
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Also known asGranzyme A PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenGZMA/Granzyme A
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SpecificityThis is a highly specific antibody against GZMA/Granzyme A.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range110-160/262
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Subcellular locationNucleus
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Granzyme A
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Gene ID number3001
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Swiss ProtP12544
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenAbundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesHFSP; CTLA3; Granzyme A; CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF; GZMA
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolGZMAP1, GZMA, SET
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Short nameAnti-GZMA/Granzyme A
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameGranzyme A Polyclonal Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namegranzyme A pseudogene 1
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Synonyms gene name
- granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) pseudogene 1
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Locus
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Discovery year2012-06-29
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegranzyme A
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Synonyms gene
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Synonyms gene name
- granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
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Synonyms name
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Locus
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Discovery year1988-05-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Granule associated serine proteases of immune defence
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSET nuclear proto-oncogene
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Synonyms gene name
- SET translocation (myeloid leukemia-associated)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-04-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- INHAT complex
- SET complex
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data