GEF H1 Antibody

• Catalog number
  bs-4202R
• Price
  Please ask
• Size
  0.1ml

• Long name
  GEF H1 Primary Polyclonal Antibody
• Also known as
  GEF H1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  GEF H1
• Specificity
  This is a highly specific antibody against GEF H1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  12-62/986
• Subcellular location
  Cytoplasm, Cell membrane
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GEF H1
• Gene ID number
  9181
• Swiss Prot
  Q92974
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  GEF; P40; GEFH1; LFP40; GEF-H1; Rho guanine nucleotide exchange factor 2; Guanine nucleotide exchange factor H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40; ARHGEF2; KIAA0651
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  GEF  
• Gene symbol
  RAPGEF5, RAPGEF6, ARHGEF2, RAPGEF2, SLC2A4RG
• Short name
  Anti-GEF H1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  GEF H1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16862
• Gene
  RAPGEF5
• Long gene name
  Rap guanine nucleotide exchange factor 5
• Synonyms gene name
  • Rap guanine nucleotide exchange factor (GEF) 5
• Synonyms
  • KIAA0277
  • GFR
  • MR-GEF
• Synonyms name
  • M-Ras-regulated GEF
• GenBank acession
  • D87467
• Locus
  7p15.3
• Discovery year
  2004-03-01
• Entrez gene record
  9771
• Pubmed identfication
  • 9039502
  • 10486569
• RefSeq identity
  • NM_012294
• VEGA ID
  OTTHUMG00000152525

Gene info

• Identity
  HGNC:20655
• Gene
  RAPGEF6
• Long gene name
  Rap guanine nucleotide exchange factor 6
• Synonyms gene
  • PDZGEF2
• Synonyms gene name
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 2
  • Rap guanine nucleotide exchange factor (GEF) 6
• Synonyms
  • RA-GEF-2
  • PDZ-GEF2
• GenBank acession
  • AF117947
• Locus
  5q31.1
• Discovery year
  2003-09-03
• Entrez gene record
  51735
• Pubmed identfication
  • 11524421
  • 12095257
• RefSeq identity
  • NM_016340
• Classification
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000162683

Gene info

• Identity
  HGNC:682
• Gene
  ARHGEF2
• Long gene name
  Rho/Rac guanine nucleotide exchange factor 2
• Synonyms gene name
  • rho/rac guanine nucleotide exchange factor (GEF) 2
  • Rho/Rac guanine nucleotide exchange factor (GEF) 2
• Synonyms
  • LFP40
  • GEF-H1
  • KIAA0651
  • P40
  • Lfc
  • GEFH1
• GenBank acession
  • AB014551
• Locus
  1q22
• Discovery year
  2000-06-09
• Entrez gene record
  9181
• Pubmed identfication
  • 9857026
  • 9734811
• RefSeq identity
  • NM_004723
• Classification
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000017464

Gene info

• Identity
  HGNC:16854
• Gene
  RAPGEF2
• Long gene name
  Rap guanine nucleotide exchange factor 2
• Synonyms gene
  • PDZGEF1
• Synonyms gene name
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 1
  • Rap guanine nucleotide exchange factor (GEF) 2
• Synonyms
  • PDZ-GEF1
  • RA-GEF
  • DKFZP586O1422
  • KIAA0313
• Synonyms name
  • Rap GEP
• GenBank acession
  • AB002311
• Locus
  4q32.1
• Discovery year
  2003-05-20
• Entrez gene record
  9693
• Pubmed identfication
  • 9205841
  • 10934204
• RefSeq identity
  • NM_014247
• Classification
  • MicroRNA protein coding host genes
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000161451

Gene info

• Identity
  HGNC:15930
• Gene
  SLC2A4RG
• Long gene name
  SLC2A4 regulator
• Synonyms
  • GEF
  • HDBP1
  • Si-1-2
  • Si-1-2-19
• Synonyms name
  • GLUT4 enhancer factor
  • Huntington's disease gene regulatory region-binding protein 1
• GenBank acession
  • AF249267
• Locus
  20q13.33
• Discovery year
  2001-06-21
• Entrez gene record
  56731
• Pubmed identfication
  • 10825161
• RefSeq identity
  • NM_020062
• VEGA ID
  OTTHUMG00000032997

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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