Fukutin Antibody

• Catalog number
  bs-13226R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Fukutin Primary Polyclonal Antibody
• Also known as
  Fukutin PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Fukutin
• Specificity
  This is a highly specific antibody against Fukutin.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Fukutin
• Gene ID number
  282969
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Fukutin, a secreted protein, is expressed in various tissues in normal individuals. Fukutin colocalizes with a Golgi marker and a granular cytoplasmic distribution, suggesting that fukutin passes through the Golgi before being packaged into secretory vesicles. Fukutin may be located in the extracellular matrix, where it interacts with and reinforces a large complex encompassing the outside and inside of muscle membranes; alternatively, as a secreted protein, fukutin may cause muscular dystrophy by an unknown mechanism. The fukutin gene is expressed at similar levels in control fetal and adult brain, but is much reduced in Fukuyama congenital muscular dystrophy (FCMD) brains. Fukutin deficiency affects the modification of glycosylation of DAG1 (α-dystroglycan), which then cannot localize or function properly and may be degraded or eluted from the extracellular surface membrane of the muscle fiber. FCMD is the first human disease known to be caused by an ancient retrotransposal integration. The gene which encodes fukutin maps to human chromosome 9q31.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  C10orf125; Chromosome 10 open reading frame 125; FUCM_HUMAN; Fucose mutarotase; FUCU; Protein fucU homolog.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Fukutin  
• Gene symbol
  FKTN, FKRP
• Short name
  Anti-Fukutin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Fukutin Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3622
• Gene
  FKTN
• Long gene name
  fukutin
• Synonyms gene
  • FCMD
• Synonyms gene name
  • Fukuyama type congenital muscular dystrophy (fukutin)
• Synonyms
  • LGMD2M
• Locus
  9q31.2
• Discovery year
  1993-12-01
• Entrez gene record
  2218
• Pubmed identfication
  • 8275093
  • 17036286
  • 17044012
• RefSeq identity
  • NM_006731
• VEGA ID
  OTTHUMG00000020425
• Locus Specific Databases
  • FCMD - Fukuyama type congenital muscular dystrophy
  • Leiden Muscular Dystrophy pages
  • LRG_434

Gene info

• Identity
  HGNC:17997
• Gene
  FKRP
• Long gene name
  fukutin related protein
• Synonyms
  • LGMD2I
  • MDC1C
  • FKTR
• GenBank acession
  • AJ314847
• Locus
  19q13.32
• Discovery year
  2003-12-04
• Entrez gene record
  79147
• Pubmed identfication
  • 11592034
  • 11741828
• RefSeq identity
  • NM_024301
• VEGA ID
  OTTHUMG00000183177
• Locus Specific Databases
  • Leiden Muscular Dystrophy Pages
  • Leiden Muscular Dystrophy pages
  • LRG_761

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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