FLASH/CASP8AP2 Antibody

• Catalog number
  bs-3657R
• Price
  Please ask
• Size
  0.1ml

• Long name
  FLASH/CASP8AP2 Primary Polyclonal Antibody
• Also known as
  FLASH/CASP8AP2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  FLASH/CASP8AP2
• Specificity
  This is a highly specific antibody against FLASH/CASP8AP2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2
• Gene ID number
  9994
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CASP 8 associated protein 2; CASP8 associated protein 2; CASP8AP2; Caspase 8 associated protein 2; CED 4; CED4; FLASH homolog; FLASH homolog RIP 25; FLASH homolog RIP25; FLICE associated huge; FLICE associated huge protein; FLICE-associated huge protein; RIP 25; RIP25; AA387232; D4Ertd659e; mKIAA1315; C8AP2_HUMAN; CASP8-associated protein 2; FLICE-associated huge protein; FLJ11208; KIAA1315; OTTMUSP00000005125; RP23-69G24.1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FLASH/CASP8AP2  
• Gene symbol
  CASP8AP2
• Short name
  Anti-FLASH/CASP8AP2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  FLASH/CASP8AP2 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  caspase 8 associated protein 2, CED-4 and FLASH and RIP25, CASP8AP2 and IDBG-94347 and ENSG00000118412 and 9994, identical protein binding, multiple, Casp8ap2 and IDBG-133238 and ENSMUSG00000028282 and 26885, BT.102649 and IDBG-632350 and ENSBTAG00000011313 and 505138

Gene info

• Identity
  HGNC:1510
• Gene
  CASP8AP2
• Long gene name
  caspase 8 associated protein 2
• Synonyms gene name
  • CASP8 associated protein 2
• Synonyms
  • FLASH
  • CED-4
  • RIP25
  • FLJ11208
  • KIAA1315
• Synonyms name
  • FLICE-associated huge protein
• GenBank acession
  • AB037736
• Locus
  6q15
• Discovery year
  1999-12-10
• Entrez gene record
  9994
• Pubmed identfication
  • 10235259
  • 17245429
  • 17003126
• RefSeq identity
  • NM_001137667
• VEGA ID
  OTTHUMG00000015212

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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