Fibulin 1 Antibody

• Catalog number
  bs-0809R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Fibulin 1 Primary Polyclonal Antibody
• Also known as
  Fibulin 1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Fibulin 1
• Specificity
  This is a highly specific antibody against Fibulin 1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Fibulin 1
• Gene ID number
  2192
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Fibulin-1 is an extracellular matrix protein often associated with fibronectin (FN) in vivo. Fibulin-1 was found to have pronounced inhibitory effects on the cell attachment and spreading promoted by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell types on FN substrata. For example, the FN-dependent haptotactic motility of breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma (A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to FN-coated Boyden chamber membranes. Cells transfected to overproduce fibulin-1 displayed reduced velocity, distance of movement and persistence time on FN substrata. Similarly, the incorporation of fibulin-1 into FN-containing type I collagen gels inhibited the invasion of endocardial cushion mesenchymal cells migrating from cultured embryonic heart explants. By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no effect on the migration of endocardial cushion cells.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Basement membrane protein 90; BM 90; FBLN; FBLN1; FIBL 1; FIBL1; Fibulin 1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Fibulin  
• Gene symbol
  FBLN1, EFEMP1, HMCN1
• Short name
  Anti-Fibulin 1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Fibulin 1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3600
• Gene
  FBLN1
• Long gene name
  fibulin 1
• Synonyms
  • FBLN
• Locus
  22q13.31
• Discovery year
  1994-02-08
• Entrez gene record
  2192
• Pubmed identfication
  • 2269669
  • 1400330
• RefSeq identity
  • NM_006486
• Classification
  • Fibulins
• VEGA ID
  OTTHUMG00000151340

Gene info

• Identity
  HGNC:3218
• Gene
  EFEMP1
• Long gene name
  EGF containing fibulin extracellular matrix protein 1
• Synonyms gene
  • DHRD
  • FBNL
• Synonyms gene name
  • fibrillin-like
  • EGF-containing fibulin-like extracellular matrix protein 1
  • EGF containing fibulin like extracellular matrix protein 1
• Synonyms
  • S1-5
  • FBLN3
  • MTLV
• Synonyms name
  • fibulin 3
• GenBank acession
  • U03877
• Locus
  2p16.1
• Discovery year
  1996-04-30
• Entrez gene record
  2202
• Pubmed identfication
  • 8812496
  • 7799918
• Classification
  • Fibulins
• VEGA ID
  OTTHUMG00000129343
• Locus Specific Databases
  • Mutations of the EGF-containing fibulin-like extracellular matrix protein 1

Gene info

• Identity
  HGNC:19194
• Gene
  HMCN1
• Long gene name
  hemicentin 1
• Synonyms gene
  • ARMD1
• Synonyms gene name
  • age-related macular degeneration 1 (senile macular degeneration)
• Synonyms
  • FBLN6
  • FIBL6
  • FIBL-6
• Synonyms name
  • fibulin 6
• GenBank acession
  • AF156100
• Locus
  1q25.3-q31.1
• Discovery year
  2005-06-03
• Entrez gene record
  83872
• Pubmed identfication
  • 11222143
• RefSeq identity
  • NM_031935
• Classification
  • Fibulins
  • I-set domain containing
• VEGA ID
  OTTHUMG00000059337

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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