FHIT Antibody

• Catalog number
  bs-1769R
• Price
  Please ask
• Size
  0.1ml

• Long name
  FHIT Primary Polyclonal Antibody
• Also known as
  FHIT PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  FHIT
• Specificity
  This is a highly specific antibody against FHIT.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  47-72/147
• Subcellular location
  Cytoplasm, Nucleus, Mitochondrion
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FHIT
• Gene ID number
  2272
• Swiss Prot
  P49789
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  FRA3B; AP3Aase; Bis(5'-adenosyl)-triphosphatase; AP3A hydrolase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein; FHIT
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FHIT  
• Gene symbol
  FHIT
• Short name
  Anti-FHIT
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  FHIT Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3701
• Gene
  FHIT
• Long gene name
  fragile histidine triad diadenosine triphosphatase
• Synonyms gene name
  • fragile histidine triad gene
  • fragile histidine triad
• Synonyms
  • FRA3B
  • AP3Aase
• Synonyms name
  • bis(5'-adenosyl)-triphosphatase
• GenBank acession
  • BC032336
• Locus
  3p14.2
• Discovery year
  1996-10-18
• Entrez gene record
  2272
• Pubmed identfication
  • 8598045
  • 9671749
  • 26181368
• RefSeq identity
  • NM_002012
• Classification
  • Histidine triad superfamily
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000158591

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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