FBXW8 Antibody

• Catalog number
  bs-8395R
• Price
  Please ask
• Size
  0.1ml

• Long name
  FBXW8 Primary Polyclonal Antibody
• Also known as
  FBXW8 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  FBXW8
• Specificity
  This is a highly specific antibody against FBXW8.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FBXW8/FBXO29
• Gene ID number
  26259
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  FBXO29, also designated F-box/WD repeat-containing protein 8 (FBXW8), is a 598 amino acid protein that contains one 40 amino acid F-box region, making it a member of the F-box family. FBXO29 also contains five WD repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Functioning as a component of the SCF complex, FBXO29 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation. FBXO29 exists as two isoforms as a result of alternative splicing events.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  F box/WD repeat containing protein 8; F box and WD40 domain containing protein 8; F-box only protein 29; F box only protein 29; FBW6; FBW8; FBX29; FBXO29; FBXW6; FBXW8_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FBXW8  
• Gene symbol
  FBXW8
• Short name
  Anti-FBXW8
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  FBXW8 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:13597
• Gene
  FBXW8
• Long gene name
  F-box and WD repeat domain containing 8
• Synonyms gene
  • FBXO29
• Synonyms gene name
  • F-box only protein 29
  • F-box and WD-40 domain protein 8
• Synonyms
  • FBX29
  • FBW6
  • FBW8
• GenBank acession
  • AF176707
• Locus
  12q24.22
• Discovery year
  2000-09-27
• Entrez gene record
  26259
• Pubmed identfication
  • 10531035
  • 10531037
• RefSeq identity
  • NM_012174
• Classification
  • F-box and WD repeat domain containing
  • WD repeat domain containing
• VEGA ID
  OTTHUMG00000169329

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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