FADD (Ser194) Antibody
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Catalog numberbs-1349R
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PricePlease ask
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Size0.1ml
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Long nameFADD (Ser194) Primary Polyclonal Antibody
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Also known asFADD (Ser194) PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenFADD Ser194
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SpecificityThis is a highly specific antibody against FADD Ser194.
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Modification sPhosphorylation
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Modification site sSer194
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic phosphopeptide derived from rat protein FADD around the phosphorylation site of Ser194
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Gene ID number266610
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityRat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenFADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesFADD phospho S194; p-FADD phospho S194; P-Fas-associated protein with death domain; FADD protein; Fas TNFRSF6 associated via death domain; Fas associated via death domain; Fas associating death domain containing protein; Fas associating protein; Fas associating protein with death domain; Fas TNFRSF6 associated via death domain; GIG 3; GIG3; Growth inhibiting gene 3 protein; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity ; MGC8528 ; MORT 1; MORT1.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolFADD
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Short nameAnti-FADD Ser194
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameFADD (Ser194) Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targetFas (TNFRSF6)-associated via death domain, MORT1, FADD and IDBG-62144 and ENSG00000168040 and 8772, identical protein binding, Plasma membranes, Fadd and IDBG-212910 and ENSMUSG00000031077 and 14082, FADD and IDBG-645056 and ENSBTAG00000018274 and 493720
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Gene info
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Identity
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Gene
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Long gene nameFas associated via death domain
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Synonyms gene name
- Fas (TNFRSF6)-associated via death domain
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-05-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Death effector domain containing
- Death inducing signaling complex
- Ripoptosome
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data