ERK5 (Ser496) Antibody

• Catalog number
  bs-5484R
• Price
  Please ask
• Size
  0.1ml

• Long name
  ERK5 (Ser496) Primary Polyclonal Antibody
• Also known as
  ERK5 (Ser496) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  ERK5 Ser496
• Specificity
  This is a highly specific antibody against ERK5 Ser496.
• Modification s
  Phosphorylation
• Modification site s
  Ser496
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  490-505/816
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human ERK5 around the phosphorylation site of Ser496 [GP(p-S)AP]
• Gene ID number
  5598
• Swiss Prot
  Q13164
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  BMK1; ERK4; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5; MAPK7
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ERK5   Ser496  
• Gene symbol
  MAPK7
• Short name
  Anti-ERK5 Ser496
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  ERK5 (Ser496) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6880
• Gene
  MAPK7
• Long gene name
  mitogen-activated protein kinase 7
• Synonyms gene
  • PRKM7
• Synonyms
  • BMK1
  • ERK5
• Synonyms name
  • BMK1 kinase
  • extracellular-signal-regulated kinase 5
• GenBank acession
  • U25278
• Locus
  17p11.2
• Discovery year
  1998-04-28
• Entrez gene record
  5598
• Pubmed identfication
  • 10072598
  • 7759517
• RefSeq identity
  • NM_139033
• Classification
  • Mitogen-activated protein kinases
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000059587

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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