DR6 Antibody

• Catalog number
  bs-7678R
• Price
  Please ask
• Size
  0.1ml

• Long name
  DR6 Primary Polyclonal Antibody
• Also known as
  DR6 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  DR6
• Specificity
  This is a highly specific antibody against DR6.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  140-170/655
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DR6
• Gene ID number
  27242
• Swiss Prot
  O75509
• Tested Applications
  FCM
• Recommended dilutions
  FCM(1:20-100)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DR6; CD358; BM-018; Tumor necrosis factor receptor superfamily member 21; Death receptor 6; TNFRSF21; UNQ437/PRO868
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DR6  
• Gene symbol
  TNFRSF21
• Short name
  Anti-DR6
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  DR6 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:13469
• Gene
  TNFRSF21
• Long gene name
  TNF receptor superfamily member 21
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 21
• Synonyms
  • DR6
  • CD358
• Synonyms name
  • death receptor 6
• GenBank acession
  • AF068868
• Locus
  6p12.3
• Discovery year
  2001-07-27
• Entrez gene record
  27242
• Pubmed identfication
  • 9714541
• RefSeq identity
  • NM_014452
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000014796

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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