CDKN1A (Ser146) Antibody

• Catalog number
  bs-5239R
• Price
  Please ask
• Size
  0.1ml

• Long name
  CDKN1A (Ser146) Primary Polyclonal Antibody
• Also known as
  CDKN1A (Ser146) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  CDKN1A Ser146
• Specificity
  This is a highly specific antibody against CDKN1A Ser146.
• Modification s
  Phosphorylation
• Modification site s
  Ser146
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human CDKN1A around the phosphorylation site of Ser146 [QT(p-S)MT]
• Gene ID number
  1026
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Activating Fragment 1; CAP20; Cation chloride cotransporter-interacting protein 1; CDK Interacting Protein 1; CDK-interacting protein 1; CDKI; CDKN 1; CDKN1; CDKN1A; CIP1; Cyclin Dependent Kinase Inhibitor 1A; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A P21; Cyclin-dependent kinase inhibitor 1A p21, Cip1; DNA Synthesis Inhibitor; MDA 6; MDA-6; MDA6; Melanoma Dferentiation Associated Protein 6; Melanoma dferentiation-associated protein 6; Melanoma dferentiation-associated protein; p21; P21 protein; p21CIP1; p21WAF; PIC1; SDI1; SLC12A9; WAF1; Wildtype p53 Activating Fragment 1; Wildtype p53-activated fragment 1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CDKN1A   Ser146  
• Gene symbol
  CDKN1A-AS1, CDKN1A
• Short name
  Anti-CDKN1A Ser146
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  CDKN1A (Ser146) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  cyclin-dependent kinase inhibitor 1A (p21, Cip1), CAP20 and CDKN1 and CIP1 and MDA-6 and P21 and p21CIP1 and SDI1 and WAF1, CDKN1A and IDBG-85033 and ENSG00000124762 and 1026, metal ion binding, nuclei, Cdkn1a and IDBG-159848 and ENSMUSG00000023067 and 12575, CDKN1A and IDBG-630156 and ENSBTAG00000008353 and 513497

Gene info

• Identity
  HGNC:42399
• Gene
  CDKN1A-AS1
• Long gene name
  CDKN1A antisense RNA 1
• Synonyms gene name
  • CDKN1A antisense RNA 1 (non-protein coding)
• Synonyms
  • p21NAT
• GenBank acession
  • BX332409
• Locus
  6p21.1
• Discovery year
  2011-07-11
• Entrez gene record
  100861512
• Pubmed identfication
  • 19008947
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:1784
• Gene
  CDKN1A
• Long gene name
  cyclin dependent kinase inhibitor 1A
• Synonyms gene
  • CDKN1
• Synonyms gene name
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1)
• Synonyms
  • P21
  • CIP1
  • WAF1
  • SDI1
  • CAP20
  • p21CIP1
  • p21Cip1/Waf1
  • p21
• GenBank acession
  • U03106
• Locus
  6p21.2
• Discovery year
  1994-05-24
• Entrez gene record
  1026
• RefSeq identity
  • NM_078467
• VEGA ID
  OTTHUMG00000014603

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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