Cdc2 Antibody

• Catalog number
  bs-50520R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Cdc2 Primary Polyclonal Antibody
• Also known as
  Cdc2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Cdc25
• Specificity
  This is a highly specific antibody against Cdc25.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Source
  Recombinant human protein purified from E.coli(His-cdc2)
• Gene ID number
  983
• Swiss Prot
  P06493
• Tested Applications
  WB, IP
• Recommended dilutions
  WB (1:2,000) IP (1 ul)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Cyclin-dependent kinases (cdk) belong to a group of protein kinases originally discovered as being involved in the regulation of the cell cycle. Cdks are also involved in the regulation of transcription and mRNA processing. A Cdk is activated by association with a cyclin, forming a cyclin-dependent kinase complex. Cdk1, also known as cell division control protein 2 (cdc2), is one of the components of the maturation promoting factor (MPF) which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Cdk1, when bound to cyclin B, allows a dividing cell to enter into mitosis from G2 and permits the transition from G1 through S in conjunction with cyclin A and cyclin E. The Cdk1 protein is constantly present throughout the cell division cycle, but its activity is finely tuned by means of protein-protein interactions and reversible phosphorylation. Cdk1 can also enhance cell migration. Increased levels of Cdk1 promote cell migration together with cyclin B2 and the actin-stabilizing protein caldesmon. Phosphorylation of caldesmon bound to actin results in the displacement of caldesmon from actin followed by the altered interaction of actin with myosin. These events contribute to increased cell migration.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CDC2; CDC28A; P34CDC2; Cyclin-dependent kinase 1; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase; CDKN1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Cdc2  
• Gene symbol
  CDK12, POLD1, CDK10
• Short name
  Anti-Cdc25
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Cdc2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:24224
• Gene
  CDK12
• Long gene name
  cyclin dependent kinase 12
• Synonyms gene
  • CRKRS
• Synonyms gene name
  • Cdc2-related kinase, arginine/serine-rich
• Synonyms
  • CRK7
  • CRKR
  • KIAA0904
• Synonyms name
  • CDC2 related protein kinase 7
• GenBank acession
  • AF227198
• Locus
  17q12
• Discovery year
  2005-12-13
• Entrez gene record
  51755
• Pubmed identfication
  • 10048485
  • 11683387
  • 19884882
• RefSeq identity
  • NM_016507
• Classification
  • Cyclin dependent kinases
• VEGA ID
  OTTHUMG00000133214
• Locus Specific Databases
  • LRG_1413

Gene info

• Identity
  HGNC:9175
• Gene
  POLD1
• Long gene name
  DNA polymerase delta 1, catalytic subunit
• Synonyms gene
  • POLD
• Synonyms gene name
  • polymerase (DNA directed), delta 1, catalytic subunit (125kD)
  • polymerase (DNA) delta 1, catalytic subunit
• Synonyms
  • CDC2
• Synonyms name
  • CDC2 homolog (S. cerevisiae)
• Locus
  19q13.3
• Discovery year
  1992-02-06
• Entrez gene record
  5424
• Pubmed identfication
  • 1722322
• Classification
  • DNA polymerases
• VEGA ID
  OTTHUMG00000183037
• Locus Specific Databases
  • LRG_785

Gene info

• Identity
  HGNC:1770
• Gene
  CDK10
• Long gene name
  cyclin dependent kinase 10
• Synonyms gene name
  • cyclin-dependent kinase (CDC2-like) 10
• Synonyms
  • PISSLRE
• GenBank acession
  • L33264
• Locus
  16q24.3
• Discovery year
  1998-11-30
• Entrez gene record
  8558
• Pubmed identfication
  • 8208557
  • 8084611
• Classification
  • Cyclin dependent kinases
  • Spliceosomal P complex
  • Spliceosomal C complex
• VEGA ID
  OTTHUMG00000138049

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products