CD31 Antibody
-
Catalog numberbs-0468R
-
PricePlease ask
-
Size0.1ml
-
-
Long nameCD31 Primary Polyclonal Antibody
-
Also known asCD31 PAb
-
CategoryPrimary Antibodies
-
ConjugationUnconjugated
-
Target AntigenCD31
-
SpecificityThis is a highly specific antibody against CD31.
-
Modification sNone
-
Modification site sUnmodified antibody
-
ClonalityPolyclonal antibody
-
Clone numberPolyclonal antibody
-
Concentration1ug per 1ul
-
Immunogen range621-650/738
-
Subcellular locationCytoplasm
-
SourceKLH conjugated synthetic peptide derived from mouse CD31
-
Gene ID number5175
-
Swiss ProtP16284
-
Tested ApplicationsFCM, IHC-P, IF(IHC-P), IF(ICC)
-
Recommended dilutionsFCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
-
Cross reactivityHuman, Mouse, Rat, Dog
-
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigenInduces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-69 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
-
Purification methodThis antibody was purified via Protein A.
-
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym namesCD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM; Platelet endothelial cell adhesion molecule; PECAM1
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolPECAM1
-
Short nameAnti-CD31
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
HostRabbit (Oryctolagus cuniculus)
-
IsotypeImmunoglobulin G (IgG)
-
Alternative nameCD31 Polyclonal Antibody
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene nameplatelet and endothelial cell adhesion molecule 1
-
Synonyms gene name
- platelet/endothelial cell adhesion molecule 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1995-11-29
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
- Immunoglobulin like domain containing
- Ig-like cell adhesion molecule family
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data