Caspase 12 Antibody

• Catalog number
  bs-1105R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Caspase 12 Primary Polyclonal Antibody
• Also known as
  Caspase 12 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Caspase 12
• Specificity
  This is a highly specific antibody against Caspase 12.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  240-290/419
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic peptide derived from mouse Caspase 12
• Gene ID number
  12364
• Swiss Prot
  O08736
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Caspase-12; CASP-12; Casp12
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• French translation
  anticorps

• Gene target
  Caspase  
• Gene symbol
  CASP12, AVEN, NLRC4
• Short name
  Anti-Caspase 12
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Caspase 12 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:19004
• Gene
  CASP12
• Long gene name
  caspase 12 (gene/pseudogene)
• Synonyms gene
  • CASP12P1
• Synonyms gene name
  • caspase 12 pseudogene 1
  • caspase 12
• GenBank acession
  • AF464191
• Locus
  11q22.3
• Discovery year
  2002-07-25
• Entrez gene record
  100506742
• Pubmed identfication
  • 12054529
  • 9038361
  • 16917906
  • 16532395
• RefSeq identity
  • NM_001191016
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000154965

Gene info

• Identity
  HGNC:13509
• Gene
  AVEN
• Long gene name
  apoptosis and caspase activation inhibitor
• Synonyms
  • PDCD12
• Synonyms name
  • cell death regulator aven
  • programmed cell death 12
• GenBank acession
  • AF283508
• Locus
  15q14
• Discovery year
  2002-09-17
• Entrez gene record
  57099
• Pubmed identfication
  • 10949025
• RefSeq identity
  • NM_020371
• VEGA ID
  OTTHUMG00000129371

Gene info

• Identity
  HGNC:16412
• Gene
  NLRC4
• Long gene name
  NLR family CARD domain containing 4
• Synonyms gene
  • CARD12
• Synonyms gene name
  • caspase recruitment domain family, member 12
• Synonyms
  • CLAN1
  • ipaf
  • CLANA
  • CLANB
  • CLANC
  • CLAND
  • CLR2.1
  • CLAN
• Synonyms name
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
  • NOD-like receptor C4
• GenBank acession
  • AF376061
• Locus
  2p22.3
• Discovery year
  2002-09-19
• Entrez gene record
  58484
• Pubmed identfication
  • 11374873
• RefSeq identity
  • NM_021209
• Classification
  • NLR family
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000152107
• Locus Specific Databases
  • LRG_1317

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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