Calpain 2 Antibody

• Catalog number
  bs-1599R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Calpain 2 Primary Polyclonal Antibody
• Also known as
  Calpain 2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Calpain 2
• Specificity
  This is a highly specific antibody against Calpain 2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic peptide derived from mouse Calpain 2
• Gene ID number
  824
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Calpain, and m calpain, also known as Calpain 2, are intracellular, calcium dependent cysteine proteases. Mu calpain has a micromolar sensitivity (thus the mu) as compared to the millimolar calcium sensitivity of m calpain. Both Calpains 1 and 2 are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. The calpains have papain like activity, thus the pain nomenclature. Both Calpain 1 and Calpain 2 are ubiquitously expressed, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain 94, ncl2, ncl3, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain 4), and a large variable subunit. It is not clear that all calpains contain a small subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Calcium activated neutral proteinase 2; Calcium activated neutral proteinase; CALP80; Calpain 2 m/II large subunit; Calpain 2 catalytic subunit; Calpain 2 large catalytic subunit; Calpain 2 large subunit; Calpain large polypeptide L2; Calpain M type; Calcium-activated neutral proteinase 2; CALP80; Calpain 2, large [catalytic] subunit; Calpain M-type; Calpain-2 catalytic subunit; Calpain-2 large subunit; CAN2_MOUSE; M-calpain; Millimolar-calpain; Calpain2; CANP 2; CANP L2; CANP2; CANPL 2; CANPL2; CANPml; Capa2; CAPN 2; CAPN2; FLJ39928; M calpain; M calpin; M type; mCANP; Millimolar calpain.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Calpain  
• Gene symbol
  CAPN8, CAPN2, CAPNS2
• Short name
  Anti-Calpain 2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Calpain 2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1485
• Gene
  CAPN8
• Long gene name
  calpain 8
• Synonyms gene name
  • calpain 8 (nCL-2)
• Synonyms
  • nCL-2
• Locus
  1q41
• Discovery year
  1998-09-25
• Entrez gene record
  388743
• Pubmed identfication
  • 7690035
  • 8889549
• RefSeq identity
  • NM_001143962
• Classification
  • Calpains
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000037378

Gene info

• Identity
  HGNC:1479
• Gene
  CAPN2
• Long gene name
  calpain 2
• Synonyms gene name
  • calpain 2, (m/II) large subunit
• Synonyms
  • mCANP
  • CANPml
  • CANPL2
• GenBank acession
  • J04700
• Locus
  1q41
• Discovery year
  1989-06-30
• Entrez gene record
  824
• Pubmed identfication
  • 2852952
  • 2539381
• RefSeq identity
  • NM_001748
• Classification
  • EF-hand domain containing
  • Calpains
• VEGA ID
  OTTHUMG00000037376

Gene info

• Identity
  HGNC:16371
• Gene
  CAPNS2
• Long gene name
  calpain small subunit 2
• Synonyms
  • MGC12536
  • MGC14804
• GenBank acession
  • AY052551
• Locus
  16q12.2
• Discovery year
  2004-07-19
• Entrez gene record
  84290
• Pubmed identfication
  • 11853546
• RefSeq identity
  • NM_032330
• Classification
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000167812

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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