BCAR1 (Tyr249) Antibody

• Catalog number
  bs-12574R
• Price
  Please ask
• Size
  0.1ml

• Long name
  BCAR1 (Tyr249) Primary Polyclonal Antibody
• Also known as
  BCAR1 (Tyr249) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  BCAR1 Tyr249
• Specificity
  This is a highly specific antibody against BCAR1 Tyr249.
• Modification s
  Phosphorylation
• Modification site s
  Tyr249
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human BCAR1 around the phosphorylation site of Tyr249
• Gene ID number
  9564
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  BCAR1 phospho Y249; BCAR1phospho Y249; p-BCAR1p-Tyr249; Breast cancer anti estrogen resistance 1 protein; BCAR 1; Bcar1; BCAR1_HUMAN; Breast cancer anti estrogen resistance 1; Breast cancer anti-estrogen resistance protein 1; CAS; Cas scaffolding protein family member 1; Crk associated substrate; Crk associated substrate p130Cas; CRK-associated substrate; CRKAS; P130CAS.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BCAR1   Tyr249  
• Gene symbol
  BCAR1
• Short name
  Anti-BCAR1 Tyr249
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  BCAR1 (Tyr249) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  breast cancer anti-estrogen resistance 1, CAS and CAS1 and CASS1 and CRKAS and P130Cas, BCAR1 and IDBG-42468 and ENSG00000050820 and 9564, protein kinase binding, nuclei, Bcar1 and IDBG-193577 and ENSMUSG00000031955 and 12927, BCAR1 and IDBG-629067 and ENSBTAG00000012002 and

Gene info

• Identity
  HGNC:971
• Gene
  BCAR1
• Long gene name
  BCAR1 scaffold protein, Cas family member
• Synonyms gene name
  • breast cancer anti-estrogen resistance 1
  • BCAR1, Cas family scaffolding protein
  • BCAR1, Cas family scaffold protein
• Synonyms
  • P130Cas
  • Crkas
  • CAS
  • CASS1
• Synonyms name
  • Crk-associated substrate
  • Cas scaffolding protein family member 1
• GenBank acession
  • AJ242987
• Locus
  16q23.1
• Discovery year
  1999-04-29
• Entrez gene record
  9564
• Pubmed identfication
  • 8413311
  • 10639512
• RefSeq identity
  • NM_014567
• Classification
  • Cas scaffold proteins
• VEGA ID
  OTTHUMG00000137604

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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