BAD (Ser75) Antibody

• Catalog number
  bs-3009R
• Price
  Please ask
• Size
  0.1ml

• Long name
  BAD (Ser75) Primary Polyclonal Antibody
• Also known as
  BAD (Ser75) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  BAD Ser75
• Specificity
  This is a highly specific antibody against BAD Ser75.
• Modification s
  Phosphorylation
• Modification site s
  Ser75
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human BAD around the phosphorylation site of Ser75
• Gene ID number
  572
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Bad phospho S75; Bad phospho Ser75; p-Bad S75;p- Bad Ser75; mouse BAD Ser112, p-Bad phospho Ser75; BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein; BAD_HUMAN; Bcl-2-binding component 6.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BAD   Ser75  
• Gene symbol
  BAD, LAMP5
• Short name
  Anti-BAD Ser75
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  BAD (Ser75) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  BCL2-associated a this GO nist of cell death, BBC2 and BCL2L8, BAD and IDBG-53423 and ENSG00000002330 and 572, protein heterodimerization activity, Cytoplasm, Bad and IDBG-137335 and ENSMUSG00000024959 and 12015, BT.55802 and IDBG-643918 and ENSBTAG00000012511 and 615013

Gene info

• Identity
  HGNC:936
• Gene
  BAD
• Long gene name
  BCL2 associated agonist of cell death
• Synonyms
  • BCL2L8
  • BBC2
• GenBank acession
  • AF021792
• Locus
  11q13.1
• Discovery year
  1997-10-16
• Entrez gene record
  572
• Pubmed identfication
  • 8929532
• RefSeq identity
  • NM_032989
• Classification
  • BCL2 homology region 3 (BH3) only
• VEGA ID
  OTTHUMG00000134302

Gene info

• Identity
  HGNC:16097
• Gene
  LAMP5
• Long gene name
  lysosomal associated membrane protein family member 5
• Synonyms gene
  • C20orf103
• Synonyms gene name
  • chromosome 20 open reading frame 103
  • lysosomal-associated membrane protein family, member 5
• Synonyms
  • dJ1119D9.3
  • BAD-LAMP
  • UNC-46
• Synonyms name
  • brain and dendritic cell associated LAMP
• GenBank acession
  • AL121740
• Locus
  20p12.2
• Discovery year
  2001-07-17
• Entrez gene record
  24141
• Pubmed identfication
  • 11780052
  • 21642595
• RefSeq identity
  • NM_012261
• Classification
  • Lysosome associated membrane proteins
• VEGA ID
  OTTHUMG00000031851

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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