ATXN1 (Ser775) Antibody

• Catalog number
  bs-3008R
• Price
  Please ask
• Size
  0.1ml

• Long name
  ATXN1 (Ser775) Primary Polyclonal Antibody
• Also known as
  ATXN1 (Ser775) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  ATXN1 Ser775
• Specificity
  This is a highly specific antibody against ATXN1 Ser775.
• Modification s
  Phosphorylation
• Modification site s
  Ser775
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human Ataxin-1 around the phosphorylation site of Ser775
• Gene ID number
  6310
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  ATXN1; ATX1; D6S504E; SCA1; Ataxin-1; Spinocerebellar ataxia type 1; ATX1_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ATXN1   Ser775  
• Gene symbol
  ATXN1-AS1, ATXN1
• Short name
  Anti-ATXN1 Ser775
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  ATXN1 (Ser775) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40515
• Gene
  ATXN1-AS1
• Long gene name
  ATXN1 antisense RNA 1
• Locus
  6p22.3
• Discovery year
  2019-07-24
• Entrez gene record
  101928433
• RefSeq identity
  • NR_136240
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:10548
• Gene
  ATXN1
• Long gene name
  ataxin 1
• Synonyms gene
  • SCA1
• Synonyms gene name
  • spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)
• Synonyms
  • D6S504E
  • ATX1
• GenBank acession
  • X79204
• Locus
  6p22.3
• Discovery year
  1986-01-01
• Entrez gene record
  6310
• Pubmed identfication
  • 1582256
• RefSeq identity
  • NM_000332
• Classification
  • Ataxins
• VEGA ID
  OTTHUMG00000014303
• Locus Specific Databases
  • LRG_863

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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