ATM Antibody

• Catalog number
  bs-1370R
• Price
  Please ask
• Size
  0.1ml

• Long name
  ATM Primary Polyclonal Antibody
• Also known as
  ATM PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  ATM
• Specificity
  This is a highly specific antibody against ATM.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  2700-2750/3066
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic peptide derived from mouse ATM
• Gene ID number
  11920
• Swiss Prot
  Q62388
• Tested Applications
  IHC-P, IF(IHC-P), IF(ICC)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  AI256621; C030026E19Rik; Serine-protein kinase ATM; Ataxia telangiectasia mutated homolog; A-T mutated homolog; Atm
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ATM  
• Gene symbol
  ATM
• Short name
  Anti-ATM
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  ATM Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  ataxia telangiectasia mutated, AT1 and ATA and ATC and ATD and ATDC and ATE and TEL1 and TELO1, ATM and IDBG-70193 and ENSG00000149311 and 472, transferase activity, nuclei, Atm and IDBG-165511 and ENSMUSG00000034218 and 11920, ATM and IDBG-629882 and ENSBTAG00000003111 and 526824

Gene info

• Identity
  HGNC:795
• Gene
  ATM
• Long gene name
  ATM serine/threonine kinase
• Synonyms gene
  • ATA
  • ATDC
  • ATC
  • ATD
• Synonyms gene name
  • ataxia telangiectasia mutated (includes complementation groups A, C and D)
  • ataxia telangiectasia mutated
• Synonyms
  • TEL1
  • TELO1
• Synonyms name
  • TEL1, telomere maintenance 1, homolog (S. cerevisiae)
• GenBank acession
  • AB209133
• Locus
  11q22.3
• Discovery year
  1995-07-07
• Entrez gene record
  472
• RefSeq identity
  • NM_000051
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000166480
• Locus Specific Databases
  • Ataxia Telangiectasia Mutated (ATM)
  • Global Variome shared LOVD
  • LRG_135

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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