ARFGEF2/BIG2 Antibody

• Catalog number
  bs-11804R
• Price
  Please ask
• Size
  0.1ml

• Long name
  ARFGEF2/BIG2 Primary Polyclonal Antibody
• Also known as
  ARFGEF2/BIG2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  ARFGEF2/BIG2
• Specificity
  This is a highly specific antibody against ARFGEF2/BIG2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ARFGEF2/BIG2
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects golgi structure, and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  ADP ribosylation factor guanine nucleotide exchange factor 2 brefeldin A inhibited; ADP ribosylation factor guanine nucleotide exchange factor 2; ARFGEF 2; ARFGEF2; ARFGEP2; BIG 2; BIG2; Brefeldin A inhibited 2; Brefeldin A inhibited GEP 2; Brefeldin A inhibited guanine nucleotide exchange protein 2; dJ1164I10.1; BIG2_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ARFGEF2/BIG2  
• Gene symbol
  ARFGEF2
• Short name
  Anti-ARFGEF2/BIG2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  ARFGEF2/BIG2 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), BIG2 and dJ1164I10.1 and PVNH2, ARFGEF2 and IDBG-80059 and ENSG00000124198 and 10564, GABA receptor binding, Cell surfaces, Arfgef2 and IDBG-212930 and ENSMUSG00000074582 and 99371, ARFGEF2 and IDBG-643137 and ENSBTAG00000007120 and 539295

Gene info

• Identity
  HGNC:15853
• Gene
  ARFGEF2
• Long gene name
  ADP ribosylation factor guanine nucleotide exchange factor 2
• Synonyms gene name
  • ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
• Synonyms
  • BIG2
• Synonyms name
  • Brefeldin A-inhibited guanine nucleotide-exchange protein 2
• GenBank acession
  • AF084521
• Locus
  20q13.13
• Discovery year
  2001-06-21
• Entrez gene record
  10564
• Pubmed identfication
  • 10212200
• RefSeq identity
  • NM_006420
• Classification
  • ARFGEF family
  • A-kinase anchoring proteins
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000032687

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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