Alpha Dystroglycan Antibody

• Catalog number
  bs-5152R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Alpha Dystroglycan Primary Polyclonal Antibody
• Also known as
  Alpha Dystroglycan PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Alpha Dystroglycan
• Specificity
  This is a highly specific antibody against Alpha Dystroglycan.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DAG1
• Gene ID number
  1605
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  AGRNR; Alpha-DG; Beta-DG; Beta-dystroglycan; beta Dystroglycan; DAG; Dag1; DAG1_HUMAN; Dystroglycan 1 dystrophin-associated glycoprotein 1; Dystroglycan; Dystrophin-associated glycoprotein 1; 156DAG; A3a; Dystrophin-associated glycoprotein 1.
• Description
  The Anti-Alpha Dystroglycan is a α- or alpha protein sometimes glycoprotein present in blood.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Alpha   Dystroglycan  
• Gene symbol
  DAG1
• Short name
  Anti-Alpha Dystroglycan
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Alpha Dystroglycan Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2666
• Gene
  DAG1
• Long gene name
  dystroglycan 1
• Synonyms gene name
  • dystroglycan 1 (dystrophin-associated glycoprotein 1)
• Synonyms
  • A3a
  • 156DAG
  • AGRNR
  • DAG
• Synonyms name
  • alpha-dystroglycan
  • dystrophin-associated glycoprotein-1
  • beta-dystroglycan
• GenBank acession
  • L19711
• Locus
  3p21.31
• Discovery year
  1997-07-22
• Entrez gene record
  1605
• Pubmed identfication
  • 7774920
  • 1741056
• VEGA ID
  OTTHUMG00000156869
• Locus Specific Databases
  • Leiden Muscular Dystrophy pages
  • LRG_854

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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