alpha B Crystallin (Ser45) Antibody
-
Catalog number
bs-12970R
-
Price
Please ask
-
Size
0.1ml
-
-
Long name
alpha B Crystallin (Ser45) Antibody
-
Also known as
alpha B Crystallin (Ser45) Antibody
-
Category
Primary Antibodies
-
Conjugation
Unconjugated
-
Target Antigen
alpha B Crystallin Ser45
-
Specificity
This is a highly specific antibody against alpha B Crystallin Ser45.
-
Modification s
Phosphorylation
-
Modification site s
Ser45
-
Clonality
Polyclonal antibody
-
Clone number
Polyclonal antibody
-
Concentration
1ug per 1ul
-
Source
KLH conjugated synthetic phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser45
-
Gene ID number
1410
-
Tested Applications
WB, IHC-P, IF(IHC-P)
-
Recommended dilutions
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
-
Cross reactivity
Human, Mouse, Rat
-
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigen
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].
-
Purification method
This antibody was purified via Protein A.
-
Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym names
alpha B Crystallin phospho S45; alpha B Crystallin phospho Ser45; p-alpha B Crystallin S45; p-alpha B Crystallin Ser45; AACRYA; Alpha B crystallin; Alpha crystallin B chain; Alpha crystallin B chain; AlphaB crystallin; AlphaB-crystallin; Alpha-crystallin B chain; CRYA2; CRYAB; CRYAB_HUMAN; Crystallin alpha B; Crystallin alpha polypeptide 2; CTPP 2; CTPP2; Heat shock 20 kD like protein; Heat shock protein beta 5; Heat shock protein beta-5; HSPB5; NY REN 27 antigen; Renal carcinoma antigen NY REN 27; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component.
-
Description
The Anti-alpha B Crystallin Ser45 is a α- or alpha protein sometimes glycoprotein present in blood.
-
Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
-
Gene target
-
Short name
Anti-alpha B Crystallin Ser45
-
Technique
Antibody, antibodies against human proteins, antibodies for
-
Host
Rabbit (Oryctolagus cuniculus)
-
Isotype
Immunoglobulin G (IgG)
-
Alternative name
alpha B Crystallin (Ser45) Antibody
-
Alternative technique
antibodies
-
MeSH Data
-
Name
-
Concept
Scope note:
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
-
Tree numbers
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Similar products