AKT1 (960CT4.5.1) Monoclonal Antibody
-
Catalog number
bsm-51238M
-
Price
Please ask
-
Size
0.1ml
-
-
Long name
AKT1 (960CT4.5.1) Monoclonal Antibody
-
Also known as
AKT1 (960CT4.5.1) Monoclonal Antibody
-
Category
Primary Antibodies
-
Conjugation
Unconjugated
-
Target Antigen
AKT1
-
Specificity
This is a highly specific antibody against AKT1.
-
Modification s
None
-
Modification site s
Unmodified antibody
-
Clonality
Monoclonal
-
Clone number
960CT4.5.1
-
Source
This AKT1 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 430-460 region of human AKT1.
-
Gene ID number
207
-
Swiss Prot
P31749
-
Tested Applications
WB
-
Recommended dilutions
WB(1:5000)
-
Cross reactivity
Human
-
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigen
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
-
Purification method
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
-
Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym names
AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; Protein kinase B; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha; AKT1
-
Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
-
French translation
anticorps
-
Gene target
-
Gene symbol
AKT1
-
Short name
Anti-AKT1
-
Technique
Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
-
Host
Mouse (Mus musculus)
-
Isotype
Immunoglobulin G (IgG)1
-
Alternative name
AKT1 (960CT4.5.1) Monoclonal Antibody
-
Alternative technique
antibodies
-
Alternative to gene target
v-akt murine thymoma viral oncogene homolog 1, AKT and CWS6 and PKB and PKB-ALPHA and PRKBA and RAC and RAC-ALPHA, AKT1 and IDBG-22709 and ENSG00000142208 and 207, phosphatidylinositol-3, nuclei, Akt1 and IDBG-174623 and ENSMUSG00000001729 and 11651, AKT1 and IDBG-635767 and ENSBTAG00000017636 and
-
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Similar products
