TSC1(Ser505) Antibody, Cy3 Conjugated

• Catalog number
  bs-5600R-Cy3
• Price
  Please ask
• Size
  0.1ml

• Long name
  TSC1(Ser505) Polyclonal Antibody, Cy3 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy3
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  TSC1 Ser505
• Specificity
  This is a highly specific antibody against TSC1 Ser505.
• Modification
  Phosphorylation
• Modification site
  Ser505
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD(p-S)PF]
• Gene ID number
  7248
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  512,550nm/570,615nm
• Synonyms
  TSC1phospho S505; LAM; TSC1; Tuberous sclerosis 1 protein.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-TSC1 Ser505 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
• Additional conjugation
  cy3 conjugation kit
• French translation
  anticorps

• Gene target
  TSC1   Ser505   Conjugated  
• Gene symbol
  TSC1
• Short name
  Anti-TSC1 Ser505
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy3
• Alternative name
  Anti-TSC1 Ser505 PAb Cy3
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12362
• Gene
  TSC1
• Long gene name
  TSC complex subunit 1
• Synonyms gene
  • TSC
• Synonyms gene name
  • tuberous sclerosis 1
• Synonyms
  • KIAA0243
  • LAM
  • hamartin
• Synonyms name
  • hamartin
• GenBank acession
  • AF013168
• Locus
  9q34
• Discovery year
  1986-01-01
• Pubmed identfication
  • 9242607
  • 10806479
• Classification
  • TSC complex
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000020844
• Locus Specific Databases
  • TSC Mutation Database
  • Global Variome shared LOVD
  • LRG_486

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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