TAK1(Ser412) Antibody, FITC Conjugated

• Catalog number
  bs-3435R-FITC
• Price
  Please ask
• Size
  0.1ml

• Long name
  TAK1(Ser412) Polyclonal Antibody, FITC Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  FITC
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  TAK1 Ser412
• Specificity
  This is a highly specific antibody against TAK1 Ser412.
• Modification
  Phosphorylation
• Modification site
  Ser412
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic phosphopeptide derived from mouse TAK1 around the phosphorylation site of Ser412
• Gene ID number
  26409
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  TAK1 (or MAP3K7) was shown to participate in regulation of transcription by transforming growth factor beta (TGF beta). TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 (TGF b activated kinase 1) MAPKKK in TGF b signal transduction. TAB1 induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF a activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against TNF a induced NFkB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  494nm/518nm
• Synonyms
  Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; MAP3K 7; MAPKKK7; Mitogen activated protein kinase kinase kinase 7; TAK1; TGF beta activated kinase 1; TGF1a; Transforming growth factor beta activated kinase 1; M3K7_MOUSE.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
• Additional conjugation
  Anti-FITC Antibody
• French translation
  anticorps

• Gene target
  TAK1   Ser412   Conjugated  
• Gene symbol
  MAP3K7, NR2C2
• Short name
  Anti-TAK1 Ser412
• Technique
  Antibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
• Isotype
  Immunoglobulin G (IgG)
• Label
  FITC
• Alternative name
  Anti-TAK1 Ser412 PAb FITC
• Alternative technique
  antibodies, fluorescine

Gene info

• Identity
  HGNC:6859
• Gene
  MAP3K7
• Long gene name
  mitogen-activated protein kinase kinase kinase 7
• Synonyms gene
  • TAK1
• Synonyms
  • MEKK7
• Synonyms name
  • TGF-beta activated kinase 1
• GenBank acession
  • AB009356
• Locus
  6q15
• Discovery year
  1998-05-22
• Entrez gene record
  6885
• Pubmed identfication
  • 9466656
• RefSeq identity
  • NM_145331
• Classification
  • Mitogen-activated protein kinase kinase kinases
• VEGA ID
  OTTHUMG00000015217
• Locus Specific Databases
  • The Globin Gene Server

Gene info

• Identity
  HGNC:7972
• Gene
  NR2C2
• Long gene name
  nuclear receptor subfamily 2 group C member 2
• Synonyms gene
  • TR4
• Synonyms gene name
  • nuclear receptor subfamily 2, group C, member 2
• Synonyms
  • TAK1
  • TR2R1
  • hTAK1
• GenBank acession
  • L27586
• Locus
  3p25.1
• Discovery year
  1998-05-15
• Entrez gene record
  7182
• Pubmed identfication
  • 8661150
  • 8016112
• RefSeq identity
  • NM_003298
• Classification
  • Nuclear receptor subfamily 2 group C
• VEGA ID
  OTTHUMG00000129839

MeSH Data

• Name
  Fluorescent Antibody Technique
• Concept
  Scope note: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
• Tree numbers
  • E01.370.225.500.607.512.240
  • E01.370.225.750.551.512.240
  • E05.200.500.607.512.240
  • E05.200.750.551.512.240
  • E05.478.583.375
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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