Senataxin/SETX Antibody, HRP Conjugated

• Catalog number
  bs-11693R-HRP
• Price
  Please ask
• Size
  0.1ml

• Long name
  Senataxin/SETX Polyclonal Antibody, HRP Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  HRP
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Senataxin/SETX
• Specificity
  This is a highly specific antibody against Senataxin/SETX.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  345-395/2677
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic peptide derived from human Senataxin
• Gene ID number
  23064
• Swiss Prot
  Q7Z333
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  ALS4; AOA2; SCAR1; bA479K20.2; Probable helicase senataxin; Amyotrophic lateral sclerosis 4 protein; SEN1 homolog; Senataxin; SETX; KIAA0625
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
• Additional conjugation
  HRP Conjugated
• French translation
  anticorps

• Gene target
  Senataxin/SETX   Conjugated  
• Gene symbol
  SETX
• Short name
  Anti-Senataxin/SETX
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  HRP
• Alternative name
  Anti-Senataxin/SETX PAb HRP
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:445
• Gene
  SETX
• Long gene name
  senataxin
• Synonyms gene
  • ALS4
  • SCAR1
• Synonyms gene name
  • amyotrophic lateral sclerosis 4
  • spinocerebellar ataxia, recessive, non-Friedreich type 1
• Synonyms
  • KIAA0625
  • AOA2
  • Sen1
• GenBank acession
  • AB014525
• Locus
  9q34.13
• Discovery year
  1996-10-26
• Entrez gene record
  23064
• Pubmed identfication
  • 9497266
  • 11022012
• RefSeq identity
  • NM_015046
• Classification
  • UPF1 like RNA helicases
  • SSU processome
• VEGA ID
  OTTHUMG00000020834
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LOVD - Leiden Open Variation Database
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_268

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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