ROCK1(Thr455/Ser456) Antibody, Cy7 Conjugated

• Catalog number
  bs-4630R-Cy7
• Price
  Please ask
• Size
  0.1ml

• Long name
  ROCK1(Thr455/Ser456) Polyclonal Antibody, Cy7 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy7
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  ROCK1 Thr455 + Ser456
• Specificity
  This is a highly specific antibody against ROCK1 Thr455 + Ser456.
• Modification
  Phosphorylation
• Modification site
  Thr455/Ser456
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  440-465/1354
• Source
  KLH conjugated synthetic phosphopeptide derived from human ROCK1 around the phosphorylation site of Thr455/Ser456
• Gene ID number
  6093
• Swiss Prot
  Q13464
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  743nm/767nm
• Synonyms
  ROCK-I; P16ROCK; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; p16 ROCK-1; ROCK1
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugated
  These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
• Additional conjugation
  Cy7
• French translation
  anticorps

• Gene target
  ROCK1   Thr455/Ser456   Conjugated  
• Gene symbol
  ROCK1
• Short name
  Anti-ROCK1 Thr455 + Ser456
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy7
• Alternative name
  Anti-ROCK1 Thr455 + Ser456 PAb Cy7
• Alternative technique
  antibodies
• Alternative to gene target
  Rho-associated, coiled-coil containing protein kinase 1, P160ROCK and ROCK-I, ROCK1 and IDBG-1371 and ENSG00000067900 and 6093, transferase activity, Plasma membranes, Rock1 and IDBG-128359 and ENSMUSG00000024290 and 19877, ROCK1 and IDBG-644080 and ENSBTAG00000008403 and 785911

Gene info

• Identity
  HGNC:10251
• Gene
  ROCK1
• Long gene name
  Rho associated coiled-coil containing protein kinase 1
• Synonyms
  • p160ROCK
• Locus
  18q11.1
• Discovery year
  1997-10-10
• Entrez gene record
  6093
• Pubmed identfication
  • 8617235
• RefSeq identity
  • NM_005406
• Classification
  • AGC family kinases
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000131723
• Locus Specific Databases
  • LRG_1005

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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