PTPN11 (Tyr584) Antibody, Biotin Conjugated

• Catalog number
  bs-3405R-Biotin
• Price
  Please ask
• Size
  0.1ml

• Long name
  PTPN11 (Tyr584) Polyclonal Antibody, Biotin Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Biotin
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  PTPN11 Tyr584
• Specificity
  This is a highly specific antibody against PTPN11 Tyr584. This phosphorylation site is homologous across the listed cross reactive species.
• Modification
  Phosphorylation
• Modification site
  Tyr584
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  550-597/597
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic phosphopeptide derived from human PTPN11 around the phosphorylation site of Tyr584
• Gene ID number
  5781
• Swiss Prot
  Q06124
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3; Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP-2C; SHP-2; PTPN11; SHPTP2
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
• Additional conjugation
  Biotinylated
• French translation
  anticorps

• Gene target
  PTPN11   Tyr584   Conjugated  
• Gene symbol
  PTPN11
• Short name
  Anti-PTPN11 Tyr584
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Biotin
• Alternative name
  Anti-PTPN11 Tyr584 PAb Biotin
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9644
• Gene
  PTPN11
• Long gene name
  protein tyrosine phosphatase non-receptor type 11
• Synonyms gene
  • NS1
• Synonyms gene name
  • Noonan syndrome 1
  • protein tyrosine phosphatase, non-receptor type 11
• Synonyms
  • BPTP3
  • SH-PTP2
  • SHP-2
  • PTP2C
  • SHP2
• Synonyms name
  • SH2 domain-containing protein tyrosine phosphatase 2
• GenBank acession
  • D13540
• Locus
  12q24.13
• Discovery year
  1993-03-03
• Entrez gene record
  5781
• Pubmed identfication
  • 7894486
  • 1280823
• Classification
  • Protein tyrosine phosphatases non-receptor type
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000134334
• Locus Specific Databases
  • LRG_614

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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