presenilin 2/PS-2 Antibody, Biotin Conjugated

• Catalog number
  bs-3815R-Biotin
• Price
  Please ask
• Size
  0.1ml

• Long name
  presenilin 2/PS-2 Polyclonal Antibody, Biotin Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Biotin
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  presenilin 2/PS-2
• Specificity
  This is a highly specific antibody against presenilin 2/PS-2.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic peptide derived from human presenilin 2/PS-2
• Gene ID number
  5664
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  AD 3L; AD 3LP; AD 4; AD 5; AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; Alzheimer disease familial type 4; E5 1; Presenilin2; Presenilin 2; Presenilin 2; PS 2; PS2; PSEN 2; PSNL 2; PSNL2; STM 2; STM2.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
• Additional conjugation
  Biotinylated
• French translation
  anticorps

• Gene target
  presenilin   2/PS-2   Conjugated  
• Gene symbol
  CAVIN2, PLA1A, TFF1, FABP3P2, PRB2, ARMCX7P, PSEN2, MIR1289-2, MIR521-2, MIR509-2
• Short name
  Anti-presenilin 2/PS-2
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Biotin
• Alternative name
  Anti-presenilin 2/PS-2 PAb Biotin
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10690
• Gene
  CAVIN2
• Long gene name
  caveolae associated protein 2
• Synonyms gene
  • SDPR
• Synonyms gene name
  • serum deprivation response (phosphatidylserine-binding protein)
  • serum deprivation response (phosphatidylserine binding protein)
  • serum deprivation response
• Synonyms
  • SDR
  • PS-p68
  • cavin-2
• Synonyms name
  • phosphatidylserine binding protein
• GenBank acession
  • AF085481
• Locus
  2q32.3
• Discovery year
  1998-10-30
• Entrez gene record
  8436
• Pubmed identfication
  • 10191091
  • 8241023
• RefSeq identity
  • NM_004657
• Classification
  • Cavins
• VEGA ID
  OTTHUMG00000154309

Gene info

• Identity
  HGNC:17661
• Gene
  PLA1A
• Long gene name
  phospholipase A1 member A
• Synonyms
  • ps-PLA1
• GenBank acession
  • AF035268
• Locus
  3q13.33
• Discovery year
  2002-11-28
• Entrez gene record
  51365
• Pubmed identfication
  • 10196188
• Classification
  • Phospholipases
• VEGA ID
  OTTHUMG00000159425

Gene info

• Identity
  HGNC:11755
• Gene
  TFF1
• Long gene name
  trefoil factor 1
• Synonyms gene
  • BCEI
• Synonyms gene name
  • breast cancer, estrogen-inducible sequence expressed in
• Synonyms
  • D21S21
  • HPS2
  • pS2
  • pNR-2
  • HP1.A
• GenBank acession
  • BC032811
• Locus
  21q22.3
• Discovery year
  2001-06-22
• Entrez gene record
  7031
• Pubmed identfication
  • 9043862
• RefSeq identity
  • NM_003225
• VEGA ID
  OTTHUMG00000086799

Gene info

• Identity
  HGNC:3558
• Gene
  FABP3P2
• Long gene name
  fatty acid binding protein 3 pseudogene 2
• Synonyms
  • FABP3-ps
  • FABP3P
• GenBank acession
  • U72237
• Locus
  13q14.11
• Discovery year
  2000-07-31
• Entrez gene record
  56677
• Pubmed identfication
  • 9256083
• VEGA ID
  OTTHUMG00000016806

Gene info

• Identity
  HGNC:9338
• Gene
  PRB2
• Long gene name
  proline rich protein BstNI subfamily 2
• Synonyms
  • PRPPRB1
  • Ps
  • cP7
• GenBank acession
  • K03208
• Locus
  12p13.2
• Discovery year
  2001-06-22
• Entrez gene record
  653247
• Pubmed identfication
  • 8554050
• RefSeq identity
  • NM_006248
• Classification
  • Proline rich proteins
• VEGA ID
  OTTHUMG00000156975

Gene info

• Identity
  HGNC:49917
• Gene
  ARMCX7P
• Long gene name
  armadillo repeat containing X-linked 7, pseudogene
• Synonyms
  • ARMCX6-ps
  • GASP10ps
• Locus
  Xq22.1
• Discovery year
  2014-03-21
• Entrez gene record
  653354
• Pubmed identfication
  • 16221301
  • 22569362
• VEGA ID
  OTTHUMG00000022036

Gene info

• Identity
  HGNC:9509
• Gene
  PSEN2
• Long gene name
  presenilin 2
• Synonyms gene
  • AD4
• Synonyms gene name
  • Alzheimer disease 4
• Synonyms
  • AD3L
  • STM2
  • PS2
• GenBank acession
  • BC006365
• Locus
  1q42.13
• Discovery year
  1995-08-30
• Entrez gene record
  5664
• Pubmed identfication
  • 7638621
• RefSeq identity
  • NM_000447
• Classification
  • Peptidase family A22
• VEGA ID
  OTTHUMG00000037563
• Locus Specific Databases
  • Alzheimer Disease & Frontotemporal Dementia Mutation Database
  • LRG_225

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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