PPP4C Antibody, Cy7 Conjugated

• Catalog number
  bs-0490R-Cy7
• Price
  Please ask
• Size
  0.1ml

• Long name
  PPP4C Polyclonal Antibody, Cy7 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy7
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  PPP4C
• Specificity
  This is a highly specific antibody against PPP4C.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  260-307/307
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic peptide derived from human PP4C
• Gene ID number
  5531
• Swiss Prot
  P60510
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-14 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  743nm/767nm
• Synonyms
  PP4; PPX; PP4C; PPH3; PPP4; Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase X; PP-X; PPP4C
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugated
  These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
• Additional conjugation
  Cy7
• French translation
  anticorps

• Gene target
  PPP4C   Conjugated  
• Gene symbol
  PPP4C
• Short name
  Anti-PPP4C
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy7
• Alternative name
  Anti-PPP4C PAb Cy7
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9319
• Gene
  PPP4C
• Long gene name
  protein phosphatase 4 catalytic subunit
• Synonyms gene name
  • protein phosphatase 4 (formerly X), catalytic subunit
  • protein phosphatase 4, catalytic subunit
• Synonyms
  • PP4
  • PPX
• Synonyms name
  • protein phosphatase X, catalytic subunit
• Locus
  16p11.2
• Discovery year
  1993-01-22
• Entrez gene record
  5531
• Pubmed identfication
  • 9177794
• RefSeq identity
  • NM_002720
• Classification
  • Protein phosphatase catalytic subunits
• VEGA ID
  OTTHUMG00000132113

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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