PCNA [Proliferation Marker] Antibody, Cy5 Conjugated
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Catalog number
bs-2007R-Cy5
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Price
Please ask
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Size
0.1ml
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Long name
PCNA [Proliferation Marker] Antibody, Cy5 Conjugated
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Category
Conjugated Primary Antibodies
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Conjugation
Cy5
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
PCNA [proliferation Marker]
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Specificity
This is a highly specific antibody against PCNA [proliferation Marker].
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Modification
Unmodified
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Modification site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen_range
220-261/261
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Subcellular location
Nucleus
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Source
KLH conjugated synthetic peptide derived from human PCNA
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Gene ID number
5111
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Swiss Prot
P12004
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen background
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
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Purification method
This antibody was purified via Protein A.
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Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission
625,650nm/670nm
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Synonyms
ATLD2; Proliferating cell nuclear antigen; PCNA; Cyclin
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Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
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Additional conjugation
Cy5.5
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French translation
anticorps
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Gene target
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Gene symbol
PCNA, PCNA-AS1
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Short name
Anti-PCNA [proliferation Marker]
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Technique
Antibody, antibodies against human proteins, antibodies for, antibody Conjugates, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA.
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Isotype
Immunoglobulin G (IgG)
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Label
Cy5
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Alternative name
Anti-PCNA [proliferation Marker] PAb Cy5
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Alternative technique
antibodies
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Gene info
Gene info
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Identity
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Gene
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Long gene name
PCNA antisense RNA 1
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Synonyms gene
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Synonyms gene name
- PCNA antisense RNA (non-protein coding)
- PCNA antisense RNA 1 (non-protein coding)
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Locus
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Discovery year
2009-08-18
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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