NMDAR2B (Tyr1336) Antibody, Biotin Conjugated

• Catalog number
  bs-5381R-Biotin
• Price
  Please ask
• Size
  0.1ml

• Long name
  NMDAR2B (Tyr1336) Polyclonal Antibody, Biotin Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Biotin
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  NMDAR2B Tyr1336
• Specificity
  This is a highly specific antibody against NMDAR2B Tyr1336. This phosphorylation site is homologous to that of Tyr1336 in Mouse and Rat.
• Modification
  Phosphorylation
• Modification site
  Tyr1336
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  1310-1360/1484
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1336
• Gene ID number
  2904
• Swiss Prot
  Q13224
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  MRD6; NR2B; hNR3; GluN2B; NMDAR2B; Glutamate receptor ionotropic, NMDA 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NR3; GRIN2B
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
• Additional conjugation
  Biotinylated
• French translation
  anticorps

• Gene target
  NMDAR2B   Tyr1336   Conjugated  
• Gene symbol
  GRIN2B
• Short name
  Anti-NMDAR2B Tyr1336
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Biotin
• Alternative name
  Anti-NMDAR2B Tyr1336 PAb Biotin
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4586
• Gene
  GRIN2B
• Long gene name
  glutamate ionotropic receptor NMDA type subunit 2B
• Synonyms gene
  • NMDAR2B
• Synonyms gene name
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B
• Synonyms
  • GluN2B
• Locus
  12p13.1
• Discovery year
  1992-09-18
• Entrez gene record
  2904
• Pubmed identfication
  • 1350383
• Classification
  • Glutamate ionotropic receptor NMDA type subunits
• VEGA ID
  OTTHUMG00000137373

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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