Histone H2A.X (Ser140) Antibody, Cy3 Conjugated
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Catalog number
bs-3185R-Cy3
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Price
Please ask
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Size
0.1ml
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Long name
Histone H2A.X (Ser140) Antibody, Cy3 Conjugated
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Category
Conjugated Primary Antibodies
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Conjugation
Cy3
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
Histone H2A.X Ser140
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Specificity
This is a highly specific antibody against Histone H2A.X Ser140. This phosphorylation site is homologous to that of Ser140 in Mouse and Rat.
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Modification
Phosphorylation
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Modification site
Ser140
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen_range
100-142/143
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Subcellular location
Nucleus
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Source
KLH conjugated synthetic phosphopeptide derived from human Histone H2AX around the phosphorylation site of Ser140
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Gene ID number
3014
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Swiss Prot
P16104
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen background
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
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Purification method
This antibody was purified via Protein A.
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Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission
512,550nm/570,615nm
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Synonyms
H2AX; H2A.X; H2A/X; Histone H2AX; Histone H2A.X; H2AFX
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Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-Histone H2A.X Ser140 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
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Additional conjugation
cy3 conjugation kit
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French translation
anticorps
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Gene target
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Gene symbol
H2AC20, H2AC7, H2AC18, H2AC8, H2AC17, H2AC11, H2AC19, H2AC15, H2AC4, H2AC13
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Short name
Anti-Histone H2A.X Ser140
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Technique
Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
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Isotype
Immunoglobulin G (IgG)
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Label
Cy3
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Alternative name
Anti-Histone H2A.X Ser140 PAb Cy3
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 20
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Synonyms gene
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Synonyms gene name
- H2A histone family, member Q
- histone 2, H2ac
- histone cluster 2, H2ac
- histone cluster 2 H2A family member c
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 7
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Synonyms gene
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Synonyms gene name
- H2A histone family, member G
- histone 1, H2ad
- histone cluster 1, H2ad
- histone cluster 1 H2A family member d
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Synonyms
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GenBank acession
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Locus
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Discovery year
1997-08-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 18
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Synonyms gene
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Synonyms gene name
- H2A histone family, member O
- histone 2, H2aa
- histone 2, H2aa3
- histone cluster 2, H2aa3
- histone cluster 2 H2A family member a3
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-09-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 8
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Synonyms gene
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Synonyms gene name
- H2A histone family, member A
- histone 1, H2ae
- histone cluster 1, H2ae
- histone cluster 1 H2A family member e
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Synonyms
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GenBank acession
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Locus
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Discovery year
1997-08-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 17
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Synonyms gene
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Synonyms gene name
- H2A histone family, member N
- histone 1, H2am
- histone cluster 1, H2am
- histone cluster 1 H2A family member m
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 11
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Synonyms gene
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Synonyms gene name
- H2A histone family, member P
- histone 1, H2ag
- histone cluster 1, H2ag
- histone cluster 1 H2A family member g
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-10-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 19
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Synonyms gene
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Synonyms gene name
- histone 2, H2aa4
- histone cluster 2, H2aa4
- histone cluster 2 H2A family member a4
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Synonyms
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GenBank acession
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Locus
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Discovery year
2006-06-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 15
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Synonyms gene
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Synonyms gene name
- H2A histone family, member D
- histone 1, H2ak
- histone cluster 1, H2ak
- histone cluster 1 H2A family member k
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 4
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Synonyms gene
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Synonyms gene name
- H2A histone family, member M
- histone 1, H2ab
- histone cluster 1, H2ab
- histone cluster 1 H2A family member b
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 13
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Synonyms gene
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Synonyms gene name
- H2A histone family, member C
- histone 1, H2ai
- histone cluster 1, H2ai
- histone cluster 1 H2A family member i
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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