HDAC1/2 (Ser423/424) Antibody, Cy3 Conjugated
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Catalog number
bs-5387R-Cy3
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Price
Please ask
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Size
0.1ml
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Long name
HDAC1/2 (Ser423/424) Polyclonal Antibody, Cy3 Conjugated
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Category
Conjugated Primary Antibodies
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Conjugation
Cy3
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
HDAC1/2 Ser423/424
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Specificity
This is a highly specific antibody against HDAC1/2 Ser423/424.
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Modification
Phosphorylation
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Modification site
Ser423/424
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Subcellular location
Nucleus
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Source
KLH conjugated synthetic phosphopeptide derived from human HDAC1 around phosphorylation site of Ser423
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Gene ID number
3065
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen background
Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. Belongs to the histone deacetylase family.
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Purification method
This antibody was purified via Protein A.
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Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission
512,550nm/570,615nm
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Synonyms
HD 1 Phospho Ser423; HD1; HDAC 1 Phospho Ser423; histone deacetylase 1 Phospho Ser423; Histone deacetylase 1 HD1 Phospho Ser423; Histone deacetylase 1; RPD3 reduced potassium dependency yeast homolog like 1; RPD3 reduced potassium dependency; RPD3; RPD3L1; HDAC2_HUMAN. HDAC2 Phospho Ser424; Histone deacetylase 2 Phospho Ser424.
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Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-HDAC1/2 Ser423/424 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
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Additional conjugation
cy3 conjugation kit
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French translation
anticorps
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Gene target
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Gene symbol
HDAC1
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Short name
Anti-HDAC1/2 Ser423/424
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Technique
Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
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Isotype
Immunoglobulin G (IgG)
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Label
Cy3
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Alternative name
Anti-HDAC1/2 Ser423/424 PAb Cy3
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Alternative technique
antibodies
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Alternative to gene target
histone deacetylase 1, this GO N-10 and HD1 and RPD3 and RPD3L1, HDAC1 and IDBG-95712 and ENSG00000116478 and 3065, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, HDAC1 and IDBG-644586 and ENSBTAG00000012698 and 404126
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Gene info
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Identity
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Gene
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Long gene name
histone deacetylase 1
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year
1996-11-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NuRD complex subunits
- Histone deacetylases, class I
- MiDAC complex subunits
- EMSY complex
- SIN3 histone deacetylase complex subunits
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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