FGFR1 (Tyr766) Antibody, Cy3 Conjugated
#
-
Catalog numberbs-3136R-Cy3
-
Price:
-
Size0.1ml
-
-
Long nameFGFR1 (Tyr766) Polyclonal Antibody, Cy3 Conjugated
-
CategoryConjugated Primary Antibodies
-
ConjugationCy3
-
Host OrganismRabbit (Oryctolagus cuniculus)
-
Target AntigenFGFR1 Tyr766
-
SpecificityThis is a highly specific antibody against FGFR1 Tyr766.
-
ModificationPhosphorylation
-
Modification siteTyr766
-
ClonalityPolyclonal
-
ClonePolyclonal antibody
-
Concentration1ug per 1ul
-
Subcellular locationCytoplasm
-
SourceKLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr766
-
Gene ID number2260
-
Tested applicationsIF(IHC-P)
-
Recommended dilutionsIF(IHC-P)(1:50-200)
-
CrossreactivityHuman, Mouse, Rat
-
Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Antigen backgroundFibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
-
Purification methodThis antibody was purified via Protein A.
-
Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
-
Excitation Emission512,550nm/570,615nm
-
SynonymsFGFR1 phospho Y766; p-FGFR1 phospho Y766; FGFR1 Tyr766; P-FLG Tyr766;FLG Tyr766;FGF Receptor 1; bFGF R; BFGFR; C FGR; CD 331; CD331; CD331 antigen; CEK; FGFBR; FGFR 1; FGFR1; Fibroblast growth factor receptor 1; FLG; FLG protein; FLJ14326; FLT 2; FLT2; Fms like tyrosine kinase 2; Fms related tyrosine kinase 2; Fms related tyrosine kinase 2 Pfefer syndrome; H2; H3; H4; H5; HBGFR; Heparin binding growth factor receptor; Hydroxyaryl protein kinase; KAL 2; KAL2; MFR; N SAM; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Basic fibroblast growth factor receptor 1.
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-FGFR1 Tyr766 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
-
Additional conjugationcy3 conjugation kit
-
French translationanticorps
-
Gene target
-
Gene symbolFGFR1
-
Short nameAnti-FGFR1 Tyr766
-
TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
-
IsotypeImmunoglobulin G (IgG)
-
LabelCy3
-
Alternative nameAnti-FGFR1 Tyr766 PAb Cy3
-
Alternative techniqueantibodies
-
Alternative to gene targetfibroblast growth factor receptor 1, bFGF-R-1 and BFGFR and CD331 and CEK and FGFBR and FGFR-1 and FLG and FLT-2 and FLT2 and HBGFR and HH2 and HRTFDS and KAL2 and N-SAM and OGD, FGFR1 and IDBG-17796 and ENSG00000077782 and 2260, transferase activity, nuclei, Fgfr1 and IDBG-143767 and ENSMUSG00000031565 and 14182, FGFR1 and IDBG-629273 and ENSBTAG00000015457 and 281768
-
Gene info
-
Identity
-
Gene
-
Long gene namefibroblast growth factor receptor 1
-
Synonyms gene
-
Synonyms gene name
- fms-related tyrosine kinase 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1992-02-25
-
Entrez gene record
-
Pubmed identfication
-
Classification
- I-set domain containing
- Receptor tyrosine kinases
- CD molecules
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data