ERCC8/CSA Antibody, Biotin Conjugated

• Catalog number
  bs-13095R-Biotin
• Price
  Please ask
• Size
  0.1ml

• Long name
  ERCC8/CSA Polyclonal Antibody, Biotin Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Biotin
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  ERCC8/CSA
• Specificity
  This is a highly specific antibody against ERCC8/CSA.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  180-230/396
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic peptide derived from human ERCC8/CSA
• Gene ID number
  1161
• Swiss Prot
  Q13216
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  CSA; CKN1; UVSS2; DNA excision repair protein ERCC-8; Cockayne syndrome WD repeat protein CSA; ERCC8
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
• Additional conjugation
  Biotinylated
• French translation
  anticorps

• Gene target
  ERCC8/CSA   Conjugated  
• Gene symbol
  ERCC8, ERCC8-AS1, RPL10A, CSH1
• Short name
  Anti-ERCC8/CSA
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Biotin
• Alternative name
  Anti-ERCC8/CSA PAb Biotin
• Alternative technique
  antibodies
• Alternative to gene target
  excision repair cross-complementing rodent repair deficiency, complementation group 8, CKN1 and CSA and UVSS2, ERCC8 and IDBG-22959 and ENSG00000049167 and 1161, protein complex binding, nuclei, Ercc8 and IDBG-181454 and ENSMUSG00000021694 and 71991, ERCC8 and IDBG-628902 and ENSBTAG00000021606 and 518857

Gene info

• Identity
  HGNC:3439
• Gene
  ERCC8
• Long gene name
  ERCC excision repair 8, CSA ubiquitin ligase complex subunit
• Synonyms gene
  • CKN1
• Synonyms gene name
  • Cockayne syndrome 1 (classical)
  • excision repair cross-complementing rodent repair deficiency, complementation group 8
  • excision repair cross-complementation group 8
• Synonyms
  • CSA
• GenBank acession
  • U28413
• Locus
  5q12.1
• Discovery year
  1995-02-07
• Entrez gene record
  1161
• Pubmed identfication
  • 8596535
• RefSeq identity
  • NM_000082
• Classification
  • WD repeat domain containing
  • ERCC excision repair associated
• VEGA ID
  OTTHUMG00000097741
• Locus Specific Databases
  • LRG_466

Gene info

• Identity
  HGNC:40220
• Gene
  ERCC8-AS1
• Long gene name
  ERCC8 antisense RNA 1
• Locus
  5q12.1
• Discovery year
  2019-07-25
• Entrez gene record
  105378991
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:10299
• Gene
  RPL10A
• Long gene name
  ribosomal protein L10a
• Synonyms gene
  • NEDD6
• Synonyms
  • Csa-19
  • L10A
• GenBank acession
  • U12404
• Locus
  6p21.31
• Discovery year
  1994-01-21
• Entrez gene record
  4736
• Pubmed identfication
  • 7609734
  • 9647638
• RefSeq identity
  • NM_007104
• Classification
  • L ribosomal proteins
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000014566

Gene info

• Identity
  HGNC:2440
• Gene
  CSH1
• Long gene name
  chorionic somatomammotropin hormone 1
• Synonyms
  • hCS-A
  • CSA
  • PL
  • CSMT
  • FLJ75407
• Synonyms name
  • chorionic somatomammotropin A
  • placental lactogen
  • choriomammotropin
• GenBank acession
  • J00118
• Locus
  17q23.3
• Discovery year
  1986-01-01
• Entrez gene record
  1442
• Pubmed identfication
  • 6208192
• RefSeq identity
  • NM_001317
• Classification
  • Growth hormone family
• VEGA ID
  OTTHUMG00000171947

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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