DC-SIGN Antibody, Cy5 Conjugated
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Catalog numberbs-2557R-Cy5
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PricePlease ask
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Size0.1ml
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Long nameDC-SIGN Polyclonal Antibody, Cy5 Conjugated
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CategoryConjugated Primary Antibodies
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ConjugationCy5
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenDC-SIGN
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SpecificityThis is a highly specific antibody against DC-SIGN.
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ModificationUnmodified
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Modification siteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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Immunogen_range354-404/404
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Subcellular locationExtracellular
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SourceKLH conjugated synthetic peptide derived from human DC-SIGN
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Gene ID number30835
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Swiss ProtQ9NNX6
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman
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Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen backgroundPathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission625,650nm/670nm
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SynonymsCDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; CD209
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PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
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Additional conjugationCy5.5
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French translationanticorps
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Gene target
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Gene symbolCD209, CLEC4M, UBTD2, WFDC21P, TSPAN14, DCSTAMP, DCX, LAMP3, PDCD1LG2, CCL18
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Short nameAnti-DC-SIGN
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TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
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IsotypeImmunoglobulin G (IgG)
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LabelCy5
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Alternative nameAnti-DC-SIGN PAb Cy5
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameCD209 molecule
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Synonyms gene name
- CD209 antigen
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-07-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Scavenger receptors
- C-type lectin domain containing
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameC-type lectin domain family 4 member M
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Synonyms gene
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Synonyms gene name
- CD299 antigen
- C-type lectin domain family 4, member M
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-09-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameubiquitin domain containing 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2006-11-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameWAP four-disulfide core domain 21, pseudogene
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Synonyms
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Synonyms name
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Locus
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Discovery year2014-06-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametetraspanin 14
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Synonyms gene
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Synonyms gene name
- transmembrane 4 superfamily member 14
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Synonyms
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GenBank acession
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Locus
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Discovery year2004-10-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tetraspanins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namedendrocyte expressed seven transmembrane protein
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Synonyms gene
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Synonyms gene name
- transmembrane 7 superfamily member 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-06-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namedoublecortin
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Synonyms gene name
- doublecortex; lissencephaly, X-linked (doublecortin)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-03-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Doublecortin superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namelysosomal associated membrane protein 3
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Synonyms gene name
- lysosomal-associated membrane protein 3
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-29
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Entrez gene record
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Pubmed identfication
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Classification
- Lysosome associated membrane proteins
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprogrammed cell death 1 ligand 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- CD molecules
- Immunoglobulin like domain containing
- Receptor ligands
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameC-C motif chemokine ligand 18
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Synonyms gene
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Synonyms gene name
- small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
- chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
- chemokine (C-C motif) ligand 18
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-01-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Chemokine ligands
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
