CXCR7/RDC1 Antibody, HRP Conjugated
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Catalog number
bs-4897R-HRP
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Price
Please ask
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Size
0.1ml
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Long name
CXCR7/RDC1 Polyclonal Antibody, HRP Conjugated
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Category
Conjugated Primary Antibodies
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Conjugation
HRP
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
CXCR7/RDC1
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Specificity
This is a highly specific antibody against CXCR7/RDC1.
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Modification
Unmodified
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Modification site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen_range
184-213/362
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Subcellular location
Extracellular
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Source
KLH conjugated synthetic peptide derived from human CXCR7/RDC1
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Gene ID number
57007
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Swiss Prot
P25106
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Tested applications
WB, IHC-P
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Recommended dilutions
WB(1:100-1000), IHC-P(1:100-500)
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Crossreactivity
Human, Mouse, Rat
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Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen background
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
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Purification method
This antibody was purified via Protein A.
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Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission
N/A
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Synonyms
RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159; Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; ACKR3
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Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
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Additional conjugation
HRP Conjugated
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French translation
anticorps
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Gene target
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Gene symbol
ACKR3, VIPR1
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Short name
Anti-CXCR7/RDC1
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Technique
Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
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Isotype
Immunoglobulin G (IgG)
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Label
HRP
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Alternative name
Anti-CXCR7/RDC1 PAb HRP
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Alternative technique
antibodies
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Alternative to gene target
chemokine (C-X-C motif) receptor 7, CXCR7 and IDBG-84146 and ENSG00000144476 and 57007, C-X-C chemokine binding, Cell surfaces, Cxcr7 and IDBG-179969 and ENSMUSG00000044337 and 12778, CXCR7 and IDBG-642053 and ENSBTAG00000018424 and 509585
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Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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