CSP Antibody, Cy5.5 Conjugated

• Catalog number
  bs-12944R-Cy5.5
• Price
  Please ask
• Size
  0.1ml

• Long name
  CSP Polyclonal Antibody, Cy5.5 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy5.5
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  CSP
• Specificity
  This is a highly specific antibody against CSP.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic peptide derived from human CSP
• Gene ID number
  80331
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Cysteine string proteins (CSPs) are synaptic vesicle-associated, secretory vesicle proteins that are involved in Ca2+-regulated exocytosis of synaptic vesicles and modulation of presynaptic transmembrane calcium fluxes in neuroendocrine and endocrine cell types. CSP contains a J-domain that binds HSP 70/HSC 70 chaperone ATPases and a membrane-targeting, palmitoylated cysteine-rich string region. CSPs may act as molecular chaperones in synapses, and mediate conformational folding of components of the vesicular exocytotic machinery. CSP is involved in the fine tuning of neurotransmission through its interaction with receptor-coupled trimeric GTP binding proteins (G proteins) and N-type Ca2+ channels. Two variants of CSP have been described: CSP1; and the 31 amino acid, C-terminally truncated isoform, CSP2. Subcellular fractionation of insulinoma cells shows CSP1 in granular fractions, while the membrane and cytosol fractions contain predominantly CSP2. The fractions also contain additional proteins, presumably CSP dimers. Furthermore, in various mammalian cell lines (including rat brain) CSP1 expression predominates CSP2 expression.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  675nm/694nm
• Synonyms
  CLN 4; CLN4; CLN4B; CSP; cysteine string protein alpha; Cysteine string protein; DJC5; DnaJ Hsp40 homolog subfamily C member 5; DnaJ homolog subfamily C member 5; DNAJC 5; Dnajc5; DNAJC5A; DNJC5_HUMAN; NCL.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
• Additional conjugation
  Cy5.5, Cy5.5
• Conjugated
  These antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.
• French translation
  anticorps

• Gene target
  CSP   Conjugated  
• Gene symbol
  DNAJC5G, DNAJC5B, GZMH, GZMB
• Short name
  Anti-CSP
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy5.5
• Alternative name
  Anti-CSP PAb Cy5.5
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:24844
• Gene
  DNAJC5G
• Long gene name
  DnaJ heat shock protein family (Hsp40) member C5 gamma
• Synonyms gene name
  • DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
• Synonyms
  • FLJ40417
  • CSP-gamma
• GenBank acession
  • AF368277
• Locus
  2p23.3
• Discovery year
  2004-03-16
• Entrez gene record
  285126
• RefSeq identity
  • NM_173650
• Classification
  • DNAJ (HSP40) heat shock proteins
• VEGA ID
  OTTHUMG00000097079

Gene info

• Identity
  HGNC:24138
• Gene
  DNAJC5B
• Long gene name
  DnaJ heat shock protein family (Hsp40) member C5 beta
• Synonyms gene name
  • DnaJ (Hsp40) homolog, subfamily C, member 5 beta
• Synonyms
  • MGC26226
  • CSP-beta
• GenBank acession
  • AF368276
• Locus
  8q13.1
• Discovery year
  2004-03-16
• Entrez gene record
  85479
• Pubmed identfication
  • 29182667
• RefSeq identity
  • NM_033105
• Classification
  • DNAJ (HSP40) heat shock proteins
• VEGA ID
  OTTHUMG00000164470

Gene info

• Identity
  HGNC:4710
• Gene
  GZMH
• Long gene name
  granzyme H
• Synonyms gene
  • CTSGL2
• Synonyms gene name
  • granzyme H (cathepsin G-like 2, protein h-CCPX)
• Synonyms
  • CGL-2
  • CCP-X
  • CTLA1
  • CSP-C
• Synonyms name
  • cathepsin G-like 2, protein h-CCPX
• GenBank acession
  • M72150
• Locus
  14q12
• Discovery year
  1990-04-09
• Entrez gene record
  2999
• Pubmed identfication
  • 2049336
• RefSeq identity
  • NM_033423
• Classification
  • Granule associated serine proteases of immune defence
• VEGA ID
  OTTHUMG00000140185

Gene info

• Identity
  HGNC:4709
• Gene
  GZMB
• Long gene name
  granzyme B
• Synonyms gene
  • CTLA1
  • CSPB
• Synonyms gene name
  • granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
• Synonyms
  • CCPI
  • CGL-1
  • CSP-B
  • CGL1
  • CTSGL1
  • HLP
  • SECT
• Synonyms name
  • fragmentin 2
  • cytotoxic serine protease B
  • cathepsin G-like 1
  • T-cell serine protease 1-3E
  • granzyme 2
  • cytotoxic T-lymphocyte-associated serine esterase 1
• GenBank acession
  • BC030195
• Locus
  14q12
• Discovery year
  1989-05-12
• Entrez gene record
  3002
• Pubmed identfication
  • 2323780
• RefSeq identity
  • NM_004131
• Classification
  • Granule associated serine proteases of immune defence
• VEGA ID
  OTTHUMG00000029369

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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